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The documents distributed here have been provided as a means to ensure timely dissemination of scholarly and technical work on a noncommercial basis. Copyright and all rights therein are maintained by the authors or by other copyright holders, notwithstanding that they have offered their works here electronically. It is understood that all persons copying this information will adhere to the terms and constraints invoked by each author's copyright. These works may not be reposted without the explicit permission of the copyright holder.

2012

The human circadian metabolome (2012)

Dallmann R., Viola A.U., Tarokha L., Cajochen C., Brown S.A.
PNAS January 31 doi: 10.1073/pnas.1114410109 (Epub ahead of print) (PDF)

Circadian preference modulates the neural substrate of conflict processing across the day (2012)

Schmidt C., Peigneux P., Leclercq Y., Sterpenich V., Vandewalle G., Phillips C., Berthomier P., Berthomier C., Tinguely G., Gais S., Schabus M., Desseilles M., Dang-Vu T., Salmon E., Degueldre C., Balteau E., Luxen A., Cajochen C., Maquet P., Collette F.
PLoS ONE 7(1): e29658 (PDF)

2011

The implications of chronobiology for psychiatry (2011)

Wirz-Justice A.
Psychiatric Times, October 2011 (PDF)

Age effects on spectral electroencephalogram activity prior to dream recall (2011)

Chellappa S., Münch M., Knoblauch V., Cajochen C.
J Sleep Res. Aug 18. doi: 10.1111/j.1365-2869.2011.00947.x (Epub ahead of print) (PDF)

Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism (2011)

Viola A.U., Chellappa S.L., Archer S.N., Pugin F., Götz T., Dijk D.J., Cajochen C.
Neurobiology of Aging Dec 12 (Epub ahead of print) (PDF)

Human cone light sensitivity and melatonin rhythms following 24-hour continuous illumination (2011)

Danilenko K.V., Plisov I.L., Cooper H.M., Wirz-Justice A., Hébert M.
Chronobiology International 28(5): 407–414 (PDF)

Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3 (2011)

Chellappa S.L., Viola A.U., Schmidt C., Bachmann V., Gabel V., Maire M., Reichert C.F., Valomon A., Götz T., Landolt H.P., Cajochen C.
J Clin Endocrinol Metab 97(3) (PDF)

Higher frontal EEG synchronization in young women with major depression: A marker for increased homeostatic sleep pressure? (2011)

Birchler-Pedross A., Frey S., Chellappa S.L., Götz T., Brunner P., Knoblauch V., Wirz-Justice A., Cajochen C.
Sleep 34(12): 1699-1706 (PDF)

A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression (2011)

Wirz-Justice A., Bader A., Frisch U., Stieglitz R.-D., Alder J., Bitzer J., Hösli I., Jazbec S., Benedetti F., Terman M., Wisner K.L., Riecher-Rössler A.
J Clin Psychiatry 27(7): 986-993 (PDF)

Can light make us bright? Effects of light on cognition sleep (2011)

Chellappa S.L., Gordijn M.C.M., Cajochen C.
In: Kerkhof G. and Van Dongen H.P.A. (Eds), Progress in Brain Research 190: 119-133 (PDF)

Zirkadiane Rhythmen und Depression: chronobiologische Behandlungsmöglichkeiten (2011)

Wirz-Justice A., Cajochen C.
Schweiz Med Forum 11(32-33): 536-541 (PDF)

Short-Term Complexity of Cardiac Autonomic Control during Sleep: REM as a Potential Risk Factor for Cardiovascular System in Aging (2011)

Viola A.U., Tobaldini E., Chellappa S.L., Rabello Casali K., Porta A., Montano N.
PLoS ONE 6(4): e19002. doi:10.1371/journal.pone.0019002 (PDF)

Serum factors in older individuals change cellular clock properties (2011)

Pagani L., Schmitt K., Meier F., Izakovic J., Roemer K., Viola A., Cajochen C., Wirz-Justice A., Brown S.A., Eckert A.
PNAS 108(17): 7218-7223 (PDF)

Cortical activation patterns herald successful dream recall after NREM and REM sleep (2011)

Chellappa S.L., Frey, S., Knoblauch, V., Cajochen, C.
Biol Psychology 87: 251-256 (PDF)

Sleep-wake cycles and cognitive functioning in schizophrenia. (2011)

Bromundt, V., Köster, M., Georgiev-Kill, A., Opwis, K., Wirz-Justice, A., Stoppe, G., Cajochen, C.
Br J Psychiatry, epub 10.1192/bjp.bp.110.078022 (PDF, Supplement)

Evening exposure to a light emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance (2011)

Cajochen, C., Frey, S., Anders, D., Späti, J., Bues, M., Pross, A., Mager, R., Wirz-Justice, A., Stefani, O. (PDF)

Non-Visual Effects of Light on Melatonin, Alertness and Cognitive Performance: Can Blue-Enriched Light Keep Us Alert? (2011)

Chellappa S,.L., Steiner, R., Blattner, P., Oelhafen, P., Götz, T., Cajochen, C.
PLoS ONE 6(1): e16429. doi:10.1371/journal.pone.0016429 (PDF)

Body Temperatures, Sleep, and Hibernation. (2011)

Kräuchi, K., Deboer, T.
Kryger Chap. 28 (PDF)

Estimation of human circadian phase via a multi-channel ambulatory monitoring system and a multiple regression model. (2011)

Kolodyazhniy, V., Späti, J., Frey, S., Götz, T., Wirz-Justice, A., Kräuchi, K., Cajochen, C., Wilhelm, F.H.
J Biol Rhythms 26: 55-67. (PDF, Supplement)

Circadian-related sleep disorders and sleep medication use in the New Zealand blind population: an observational prevalence survey. (2011)

Warman, G.R., Pawley, M.D.M., Bolton, C., Cheeseman, J.F., Fernando, A.T., Arendt, J., Wirz-Justice, A.
PLoS ONE 6(7): e22073 (PDF)

2010

Heart-rate variability in women during 40-hour prolonged wakefulness. (2010)

Anders, D. , Vollenweider, S., Cann, J., Hofstetter, M., Flammer, J., Örgül, S., Kräuchi, K.
Chronobiology International 27(8): 1609-1628. (PDF)

Schwangerschaftsdepression und deren Behandlung. (2010)

Bader A, Frisch U, Wirz-Justice A, Riecher-Rössler
Nervenarzt, 81: 267-276. (PDF)

Systemic and Cellular Reflections on ageing and the circadian oscillator - A Mini-Review. (2010)

Brown, S.A., Pagani, L., Cajochen, C., Eckert, A.
Gerontology. Oct 28. (PDF)

Structure validity of the Pittsburgh Sleep Quality Index in renal transplant recipients: A confirmatory factor analysis. (2010)

Burkhalter, H., Sereika, S. M., Engberg, S., Wirz-Justice, A., Steigers, J., De Geest, S.
Sleep and Biological Rhythms 2010; 8: 274-281 (PDF)

What keeps us awake?--the role of clocks and hourglasses, light, and melatonin. (2010)

Cajochen, C., Chellappa, S., Schmidt, C.
Int Rev Neurobiol 93:57-90. (PDF)

Phase relationship between skin temperature and sleep-wake rhythms in women with vascular dysregulation and controls under real-life conditions. (2010)

Gompper, B., Bromundt, V., Orgül, S., Flammer, J., Kräuchi, K.
Chronobiol Int. 27(9-10):1778-96. (PDF)

Acute effects of bright light exposure on cortisol levels. (2010)

Jung, C.M., Khalsa, S.B., Scheer, F.A., Cajochen, C., Lockley, S.W., Czeisler, C.A., Wright, K.P. Jr.
J Biol Rhythms. 25(3):208-16. (PDF)

Efficacy of the novel antidepressant Agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: A randomized, double-blind comparison with Sertraline. (2010)

Kasper, S., Hajak, G., Wulff, K., Hoogendijk, W.J.G., Montejo, A.L., Smeraldi, E., Rybakowski, J.K., Quera-Salva, M.-A., Wirz-Justice, A., Picarel-Blanchot, F., Baylé, F.J.
J Clin Psychiatry 71(2): 109-120. (PDF)

Technik der rektalen Körperkerntemperaturm. (2010)

Kurt Kräuchi
DGSM · Schulz · Geisler · Rodenbeck - Kompendium Schlafmedizin - 16. Erg. Lfg. 8/10essung (PDF)

The interrelationship between sleep regulation and thermoregulation. (2010)

Kräuchi, K., Deboer, T.
Front Biosci. 1;15:604-25. (PDF)

Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population. (2010)

Mozaffarieh, M., Fontana Gasio, P., Schötzau, A., Orgül, S., Flammer, J., Kräuchi, K.
Popul Health Metr. 4;8:17. (PDF)

The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. (2010)

Pagani L, Semenova EA, Moriggi E, Revell VL, Hack LM, Lockley SW, Arendt J, Skene DJ, Meier F, Izakovic J, Wirz-Justice A, Cajochen C, Sergeeva OJ, Cheresiz SV, Danilenko KV, Eckert A, Brown SA
PLoS One. 15;5(10):e13376. (PDF)

The circadian rest-activity cycle in Korsakoff psychosis. (2010)

Wirz-Justice, A., Schröder, C.M., Fontana Gasio, P., Cajochen, C., Savaskan, E.
Am J Geriatr Psychiatry 18(1): 33-41. (PDF)

Chronotherapeutics: An example of translational research for sleep and mood disorders. (2010)

Wirz-Justice, A. (2010)
Sleep and Biological Rhythms 8: 161-162. (PDF)

2009

Subjective well-being is modulated by circadian phase, sleep pressure, age, and gender. (2009)

Birchler-Pedross, A., Schröder, C.M., Münch, M., Knoblauch, V., Blatter, K., Schnitzler-Sack, C., Wirz-Justice, A., Cajochen, C.
Journal of Biological Rhythms, 24(3): 232-242. (PDF)

Does the circadian modulation of dream recall modify with age? (2009)

Chellappa, S.L., Münch, M., Blatter, K., Knoblauch, V., C., Cajochen, C.
Sleep, 32(9): 1201-1209. (PDF)

Chronobiology, excessive daytime sleepiness and depression: Is there a link? (2009)

Chellappa, S.L., Schröder, C., Cajochen, C.
Sleep Medicine, 10(5): 505-514. (PDF)

Human retinal light sensitivity and melatonin rhythms following four days in near darkness'. (2009)

Danilenko, K.V. , Plisov, I.L., Wirz-Justice, A., Hébert, M.
Chronobilogy International, 26(1): 93-107. (PDF)

Consequences of the timing of menarche on female adolescent sleep phase preference. (2009)

Frey, S., Balu, S., Greusing, S., Rothen, N., Cajochen, C.
PLoS ONE, 4(4). (PDF)

Age-dependent alterations in human PER2 levels after early morning blue light exposure. (2009)

Jud, C., Chappuis, S., Revell, V.L., Sletten, T.L., Saaltink, D.-J., Cajochen, C., Skene, D.J., Albrecht, U.
Chronobiology International, 26(7): 1462-1469. (PDF)

The Tick-Tock of Language: Is Language Processing Sensitive to Circadian Rhythmicity and Elevated Sleep Pressure? (2009)

Rosenberg, J., Pusch, K., Dietrich, R., Cajochen, C.
Chronobiology International, 26(5): 1-18. (PDF)

Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. (2009)

Schmidt, C., Collette, F., Leclercq, Y., Sterpenich, V., Vandewalle, G., Berthomier, P., Berthomier, C., Phillips, C., Tinguely, G., Darsaud, A., Gais, S., Schabus, M., Desseilles, M., Dang-Vu, T.T., Salmon, E., Balteau, E., Dequeldre, C. Luxen, A., Maquet, P., Cajochen, C., Peigneux, P.
Science, 324(5926):516-519. (PDF)

Impact of age, sleep pressure and circadian phase on time-of-day estimates. (2009)

Späti, J., Münch, M., Blatter, K., Knoblauch, V., Jones, L.A., Cajochen, C.
Behav Brain Res, 201(1):48-52. (PDF)

Einfluss erhöhter Lichtintensität auf die Verweildauer von stationär behandelten depressiven Patienten. Vergleich der stationären Behandlungszeit 2006 und 2007 im Vivantes Klinikum Berlin Spandau. (2009)

Staedt, J., Pless-Steinkamp, C., Herfeld, F., Gudlowski, Y., Wirz-Justice, A.
Nervenheilkunde, 28: 223-226. (PDF)

Relationship between gender role, anger expression, thermal discomfort and sleep onset latency in women. (2009)

Von Arb , M., Gompper, B., Meyer, A.H., Zemp Stutz, E., Orgul, S., Flammer, J., Kräuchi, K.
BioPsychoSocial Medicine 3(11). (PDF)

Circadian disruption and psychiatric disorders: The importance of entrainment. (2009)

Wirz-Justice, A., Bromundt, V., Cajochen, C.
Sleep Med Clin, 4: 273-284. (PDF)

From the basic neuroscience of circadian clock function to light therapy for depression: On the emergence of chronotherapeutics. (2009)

Wirz-Justice, A., (2009)
Journal of Affective Disorders, 116(3): 159-160. (PDF)

2008

Interhemispheric EEG asymmetries during unilateral bright-light exposure and subsequent sleep in humans. (2008)

Cajochen, C. , Di Biase, R., Imai, M.
Am J Physiol Regulatory Integrative Comp Physiol 294:1053-1060. (PDF)

Influence of timed nutrient diet on depression and light sensitivity in seasonal affective Disorder. (2008)

Danilenko, K.V., Plisov, I.L., Hébert, M., Kräuchi, K., Wirz-Justice, A.
Chronobiology International, 25(1): 51-64. (PDF)

Cold extremities and difficulties initiating sleep: evidence of co-morbidity from a random sample of a Swiss urban population. (2008)

Kräuchi, K., Fontana Gasio, P., Vollenweider, S., Von Arb, M., Dubler, B., Orgül, S., Flammer, J., Zemp Stutz, E.
J. Sleep Res., 17: 420-426. (PDF)

Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young women. (2008)

Schachinger, H., Blumenthal, T.D., Richter, S., Savaskan, E., Wirz-Justice, A., Kräuchi, K.
Hormones and Behavior 54: 258-262. (PDF)

Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment. (2008)

Vollenweider, S., Wirz-Justice, A., Flammer, J., Orgül, S., Kräuchi, K.
Am J Physiol Regul Integr Comp Physiol, 294: 630-638. (PDF)

Diurnal variation of depressive symptoms. (2008)

Wirz-Justice, A.
Dialogues in Clinical Neuroscience 10(3): 327-333. (PDF)

2007

Circadian rhythms in cognitive performance: Methodological constraints, protocols, theoretical underpinnings. (2007)

Blatter, K., Cajochen, C.
Physiology & Behavior, 90: 196-208. (PDF)

Alerting effects of light. (2007)

Cajochen, C.
Sleep Med Rev, 11: 453-464. (PDF)

The thermophysiologcial cascade leading to sleep initiation in relation to phase of entrainment. (2007)

Kräuchi, K.
Sleep Med Rev,11: 439-451. (PDF)

The human sleep�wake cycle reconsidered from a thermoregulatory point of view. (2007)

Kräuchi, K.
Physiology & Behavior, 90: 236�245. (PDF)

Is homeostatic sleep regulation under low sleep pressure modified by age? (2007)

Münch, M., Knoblauch, V., Blatter, K., Wirz-Justice, A., Cajochen, C.
Sleep, 30(6): 781-792. (PDF)

Coping with jet-lag: A Position Statement for the European College of Sport Science. (2007)

Reilly, T., Atkinson, G., Edwards, B., Waterhouse, J., Akerstedt, T., Davenne, D., Lemmer, B., Wirz-Justice, A.
European Journal of Sport Science, 7(1): 1-7. (PDF)

A time to think: circadian rhythms in human cognition. (2007)

Schmidt, C., Collette, F., Cajochen, C., Peigneux, P.
Cogn Neuropsychol., 24(7):755-789. (PDF)

Chronobiological characterization of women with primary vasospastic syndrome: Body heat loss capacity in relation to sleep initiation and phase of entrainment. (2007)

Vollenweider, S., Wirz-Justice, A., Flammer, J., Orgül, S., Kräuchi, K.
Am J Physiol Regul Integr Comp Physiol., doi:10.1152/ajpregu.00609.2007. (PDF)

Chronobiology and psychatry. (2007)

Wirz-Justice, A.
Sleep Med Rev, 11: 423-427. (PDF)

How to measure circadian rhythms in humans. (2007)

Wirz-Justice, A.
Medicographia, 29(1): 84-90. (PDF)

2006

Gender and age differences in psychomotor vigilance under differential sleep pressure conditions. (2006)

Blatter, K., Graw, P., Münch, M., Knoblauch, V., Wirz-Justice, A., Cajochen, C.
Behavioural Brain Research, 168: 312-317. (PDF)

Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans (2006)

Cajochen, C., Jud, C., Münch, M., Kobialka, S., Wirz-Justice, A., Albrecht, U.
European Journal of Neuroscience, 23: 1082-1086. (PDF)

Age-related changes in the circadian and homeostatic regulation of human sleep. (2006)

Cajochen, C., Münch, M., Knoblauch, V., Blatter, K., Wirz-Justice, A.
Chronobiology International, 23: 461-474. (PDF)

Thermoregulatory effects of melatonin in relation to sleepiness. (2006)

Kräuchi, K., Cajochen, C., Pache, M., Flammer, J., Wirz-Justice, A.
Chronobiology International, 23: 475-484. (PDF)

Challenging the sleep homeostat does not influence the thermoregulatory system in men: evidence from a nap vs. sleep-deprivation study. (2006)

Kräuchi, K., Knoblauch, V., Wirz-Justice, A., Cajochen, C.
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 290: R1052-R1061. (PDF)

Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men. (2006)

Münch, M., Kobialka, S., Steiner, R., Oelhafen, P., Wirz-Justice, A., Cajochen, C.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 290 : R1421-R1428. (PDF)

Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine. (2006)

Savaskan, E., Schnitzler, C., Schröder, C., Cajochen, C., Müller-Spahn, F., Wirz-Justice, A.
International Journal of Neuropsychopharmacology, 9: 507-516. (PDF)

Encoding difficulty promotes postlearning changes in sleep spindle activity during napping. (2006)

Schmidt, C., Peigneux, P., Muto, V., Schenkel, M., Knoblauch, V., Münch, M., de Quervain, D. J.-F., Wirz-Justice, A., Cajochen, C.
Journal of Neuroscience, 26(35): 8976-8982. (PDF)

Biological rhythm disturbances in mood disorders (2006)

Wirz-Justice, A.
International Clinical Psychopharmacology, 21 (suppl 1): 11-15. (PDF)

2005

Sleep loss-related decrements in planning performance in healthy elderly depend on task difficulty. (2005)

Blatter, K., Opwis, K., Münch, M., Wirz-Justice, A., Cajochen, C.
Journal of Sleep Research, 14: 409-417. (PDF)

Transient short free running circadian rhythm in a case of aneurysm near the suprachiasmatic nuclei. (2005)

Bloch, K.E., Brack, T., Wirz-Justice, A.
Journal of Neurology, Neurosurgery and Psychiatry, 76: 1178-1180. (PDF, Supplement)

Schlafstörungen bei Schichtarbeit und Jetlag und die Rolle der inneren Uhr. (2005)

Cajochen, C.
Praxis, 94: 1479-1483. (PDF)

TAK-375 Takeda. (2005)

Cajochen, C.
Current Opinion in Investigational Drugs, 6: 114-121.

High sensitivity of human melatonin, alertness, thermoregulation and heart rate to short wavelength light. (2005)

Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., Wirz-Justice, A.
Journal of Clinical Endocrinology and Metabolism, 90: 1311-1316. (PDF)

Age-Related Changes in the Circadian Modulation of Sleep-Spindle Frequency During Nap Sleep. (2005)

Knoblauch, V., Münch, M., Blatter, K., Martens, W.L.J., Schröder, C., Schnitzler, C., Wirz-Justice, A., Cajochen, C.
Sleep, 28: 1093-1101 (PDF)

Thermophysiologic aspects of the three-process-model of sleepiness regulation. (2005)

Kräuchi, K., Cajochen, C. & Wirz-Justice, A.
Clinics in Sports Medicine, 24: 287-300. (PDF, Supplement)

Schlaf und zirkadiane Rhythmik im Alter. (2005)

Münch, M., Cajochen, C., Wirz-Justice, A.
Zeitschrift für Gerontologie und Geriatrie, 38 (Supplement 1) I/21�I/23. (PDF)

Age-related attenuation of the evening circadian arousal signal in humans. (2005)

Münch, M., Knoblauch, V., Blatter, K., Schröder, C., Schnitzler, C., Kräuchi, K., Wirz-Justice, A., Cajochen, C.
Neurobiology of Aging, 26: 1307-1319 (PDF)

Chronobiological strategies for unmet needs in the treatment of depression. (2005)

Wirz-Justice, A.
Medicographia, 27: 223-227 (PDF)

Chronotherapeutics (light and wake therapy) in affective disorders. (2005)

Wirz-Justice, A., Benedetti, F., Berger, M., Lam, R.W., Martiny, K., Terman, M., & Wu, J.
Psychological Medicine, 35: 939-944, (PDF)

Rütger Wever: An Appreciation. (2005)

Wirz-Justice, A., Daan, S., Folkard, S., Lewy, A., Lund, R., Zulley, J.
Journal of Biological Rhythms, 20: 554-556. (PDF)

2004

Circadian and sleep-wake dependent impact on neurobehavioral function. (2004)

Cajochen, C., Blatter, K., Wallach, D.
Psychologica Belgica, 44: 59-80. (PDF)

Circadian modulation of sequence learning under high and low sleep pressure conditions. (2004)

Cajochen, C., Knoblauch, V., Wirz-Justice, A., Kräuchi, K., Graw, P. & Wallach, D.
Behavioural Brain Research, 151: 167-176. (PDF)

Circadian and wake-dependent modulation of fastest and slowest reaction times of the Psychomotor Vigilance Task (PVT). (2004)

Graw, P., Kräuchi, K., Knoblauch, V., Renz, C., Wirz-Justice, A. & Cajochen, C.
Physiology & Behavior, 80: 695-701. (PDF)

Waking up properly: is there a role of thermoregulation in sleep inertia? (2004)

Kräuchi, K., Cajochen, C. & Wirz-Justice, A.
Journal of Sleep Research, 13: 121-127. (PDF)

Kohlenhydrate und SAD. In: S.Kasper, H.-J. Møller (Eds.) Herbst/Winterdepression und Lichttherapie (2004)

Kräuchi, K. & Wirz-Justice, A.
Springer Verlag, Wien, pp 321-326. (PDF)

The frontal predominance in human EEG delta activity after sleep loss decreases with age. (2004)

Münch, M., Knoblauch, V., Blatter, K., Schröder, C., Schnitzler, C., Kräuchi, K., Wirz-Justice, A. & Cajochen, C.
European Journal of Neuroscience, 20: 1402-10. (PDF)

Orexins and their receptors in the human retina. (2004)

Savaskan, E., Müller-Spahn, F., Meier, F., Wirz-Justice, A., Meyer, P.
Pathobiology. 71: 211-216.

Brightening Depression. (2004)

Wirz-Justice, A., Terman, M., Oren, D.A., Goodwin, F.K., Kripke, D.F., Whybrow, P.C., Wisner, K.L., Wu, J.C., Lam, R.W., Berger, M., Danilenko, K.V., Kasper, S., Smeraldi, E., Takahashi, K., Thompson, C., van den Hoofdakker, R.H.
Science, 303: 467-468. (PDF)

Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onset. (2004)

Wirz-Justice, A., Kräuchi, K., Cajochen, C., Danilenko, K.V., Renz, C. & Weber, J.
Journal of Pineal Research, 36: 192-194. (PDF)

Circadiane und saisonale Rhythmen. In: S.Kasper, H.-J.Møller (Eds.) Herbst/Winterdepression und Lichttherapie (2004)

Wirz-Justice, A. & Roenneberg, T.
Springer Verlag, Wien, pp 203-212. (PDF)

Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness. (2004)

Wyatt, J.K., Cajochen, C., Ritz-De Cecco, A., Czeisler, C.A. & Dijk, DJ.
Sleep, 27: 374-381.

2003

Electroencephalographic activity during wakefulness, rapid eye movement, and non-rapid- eye movement sleep in humans: comparison of their circadian and homeostatic modulation. (2003)

Cajochen, C.& Dijk, D.-J.
Sleep and Biological Rhythms, 2: 85-95. (PDF)

Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation. (2003)

Cajochen, C., Jewett, M.E. & Dijk, D.J.
Journal of Pineal Research, 35: 149-157. (PDF)

Role of melatonin in the regulation of human circadian rhythms and sleep. (2003)

Cajochen, C., Kräuchi, K. & Wirz-Justice, A.
Journal of Neuroendocrinology, 15: 432-437. (PDF)

Is sleep per se a zeitgeber in humans? (2003)

Danilenko, K.V., Cajochen, C. & Wirz-Justice, A.
Journal of Biological Rhythms, 18: 170-178. (PDF)

Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly. (2003)

Fontana Gasio, P., Kräuchi, K., Cajochen, C., van Someren, E.J.W., Amrhein, I., Pache, M., Savaskan, E. & Wirz-Justice, A.
Experimental Gerontology, 38: 207-216. (PDF)

A phase-response curve to single bright light pulses in human subjects. (2003)

Khalsa, S.B., Jewett, M.E., Cajochen, C. & Czeisler, C.A.
Journal of Physiology, 549: 945-52.

Human sleep spindle characteristics after sleep deprivation. (2003)

Knoblauch, V., Martens, W.J.L., Wirz-Justice, A. & Cajochen, C.
Clinical Neurophysiology, 114: 2258-2267. (PDF)

Regional differences in the circadian modulation of human sleep spindle characteristics. (2003)

Knoblauch, V., Martens, W.J.L., Wirz-Justice, A., Kräuchi, K. & Cajochen, C.
European Journal of Neuroscience, 18: 155-163. (PDF)

Colour deficiencies in Alzheimer's Disease. (2003)

Pache, M., Smeets, C.H.W., Fontana Gasio, P., Savaskan, E., Flammer, J., Wirz- Justice, A. & Kaiser, H.J.
Age and Ageing, 32: 422-426.

Life between clocks: daily temporal patterns of human chronotypes. (2003)

Roenneberg, T., Wirz-Justice, A. & Merrow, M.
Journal of Biological Rhythms, 18: 80-90. (PDF)

Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. (2003)

Savaskan, E., Olivieri, G., Meier, F., Seifritz, E., Wirz-Justice, A., Muller-Spahn, F.
Gerontology, 49: 380-383.

Seasonality in affective disorders in Switzerland. (2003)

Wirz-Justice, A., Graw, P., Kräuchi, K. & Wacker, H.R.
Acta Psychiatrica Scandinavica, 108 (Suppl. 418): 92-95. (PDF)

2002

Separation of circadian and wake-duration dependent modulation of EEG activation during wakefulness. (2002)

Cajochen, C., Wyatt, J. K., Czeisler, C. A. & Dijk, D. J.
Neuroscience, 114: 1047-60.

Homeostatic control of slow wave- and spindle frequency activity during human sleep: effect of differential sleep pressure and brain topography. (2002)

Knoblauch, V., Kräuchi, K., Renz, C., Wirz-Justice, A., & Cajochen, C.
Cerebral Cortex, 12: 1092-1100. (PDF)

How is the circadian rhythm of core body temperature regulated? (2002)

Kräuchi, K.
Clinical Autonomic Research, 12: 147-149. (PDF)

Alteration of internal circadian phase relationships after timed CHO-rich meals in humans. (2002)

Kräuchi, K., Cajochen, C., Werth, E. & Wirz-Justice A.
Journal of Biological Rhythms, 17: 364-376. (PDF)

Melatonin MT1-receptors in the human eye. (2002)

Meyer, P., Pache, M., Loeffler, K.U., Brydon, L., Jockers, R., Flammer, J., Wirz-Justice, A., Savaskan, E.
British Journal of Ophthalmology, 86: 1053-1057.

Effect of melatonin on vascular responses of porcine ciliary arteries. (2002)

Pache, M., Kräuchi, K., Haefliger, I.O., Wirz-Justice, A., Flammer, J. & Meyer, P.
Current Eye Research, 24: 313-317.

Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's Disease patients. (2002)

Savaskan, E., Olivieri, G., Meier, F., Brydon, L., Jockers, R., Ravid, R., Wirz-Justice, A. & Müller-Spahn, F.
Journal of Pineal Research, 32: 59-62. (PDF)

Distribution of melatonin MT1-receptor in human retina. (2002)

Savaskan, E., Wirz-Justice, A., Olivieri, G., Pache, M., Kräuchi, K., Brydon, L., Jockers, R., Müller-Spahn, F. & Meyer, P.
The Journal of Histochemistry and Cytochemistry, 50: 519-526. (PDF)

Decline in long-term circadian rest-activity cycle organisation in a demented patient. (2002)

Werth, E., Savaskan, E., Knoblauch, V., Fontana Gasio, P., Van Someren, E.J.W., Hock, C. & Wirz-Justice, A.
Journal of Geriatric Psychiatry and Neurology, 15: 55-59.

Lichttherapie. In: Gaebel, W. & Müller-Spahn, F. (Eds.) Diagnostik und Therapie Psychischer Störungen (2002)

Wirz-Justice, A. & Graw, P.
Kohlhammer Verlag Stuttgart, C. 1.3.6.14., 948-953.

No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration. (2002)

Wirz-Justice, A., Werth, E., Renz, C., Muller, S., Kräuchi, K.
Journal of Pineal Research, 32: 1-5. (PDF)

2001

Dynamics of frontal EEG activity, sleepiness and body temperature under high and low sleep pressure. (2001)

Cajochen, C., Knoblauch, V.,Kräuchi, K., Renz, C. & Wirz-Justice, A.
Neuroreport 12: 2277-2281. (PDF)

Early morning melatonin administration impairs psychomotor vigilance. (2001)

Graw, P., Werth, E., Kräuchi, K., Gutzwiller, F., Cajochen, C. & Wirz-Justice, A.
Behavioural Brain Research, 121: 167-172. (PDF)

Circadian clues to sleep onset mechanisms. (2001)

Kräuchi, K. & Wirz-Justice, A.
Neuropsychopharmacology, 25: 92-96. (PDF)

Cold feet and prolonged sleep-onset latency in vasospastic syndrome. (2001)

Pache, M.,Kräuchi, K., Cajochen, C., Wirz-Justice, A., Dubler, B., Flammer, J. & Kaiser, H.J.
The Lancet, 358: 125-126. (PDF)

Cerebrovascular melatonin 1a-receptor alterations in Alzheimer's Disease. (2001)

Savaskan, E., Olivieri, G., Meier, F., Brydon, L., Jockers, R., Kräuchi, K., Wirz-Justice, A. & Müller-Spahn, F.
Neuroscience Letters 308: 9-12. (PDF)

Treatment tools in chronobiology. (2001)

Wirz-Justice, A
La Revue de Médecine Interne, 22: 37-38.

An underlying circannual rhythm in seasonal affective disorder? (2001)

Wirz-Justice, A., Kräuchi, K. & Graw, P.
Chronobiology International, 18: 309-313.

Disturbed circadian rest-activity cycles in schizophrenia patients: an effect of drugs? (2001)

Wirz-Justice, A.,Haug, H.J., Cajochen, C.
Schizophr. Bull. 27: 497-502 (PDF)

Carbohydrate intake. In: Partonen, T. & Magnusson, A. (Eds.) Seasonal affective disorder: practice and research. (2001)

Kräuchi, K. & Wirz-Justice, A.
Oxford University Press, New York, C. 20, 1

2000

In what circumstances is melatonin a useful sleep therapy? (2000)

Arendt, J., Czeisler, C.A., Dawson, D., Dijk, D.-J., Lavie, P., Lewy, A.J., Parkes, J.D., Skene, D.J., Stone, B.M., Wirz-Justice, A. & Zhadnova, I.
Consensus statement, WFSRS Focus Group, Dresden, November 1999. Journal of Sleep Research, 9: 397-398.

EEG and subjective sleepiness during extended wakefulness in Seasonal Affective Disorder: circadian and homeostatic influences. (2000)

Cajochen, C., Brunner, D.P., Kräuchi, K., Graw, P. & Wirz-Justice A
Biological Psychiatry, 47: 610-617. (PDF)

Dose-response relationship for light intensity and ocular and electroencephalo-graphic correlates of human alertness. (2000)

Cajochen, C., Zeitzer, J. M., Czeisler, C.A., Dijk, D.-J.
Behavioural Brain Research 115: 75 - 83 (PDF)

Phase advance after one or three simulated dawns in humans. (2000)

Danilenko, K.V., Wirz-Justice, A., Kräuchi, K., Cajochen, C., Weber, J.M., Fairhurst, S. & Terman, M.
Chronobiology International, 17: 659-668.

The human circadian pacemaker can see by the dawn's early light. (2000)

Danilenko, K.V., Wirz-Justice, A., Kräuchi, K., Weber, J.M., Terman, M.
Journal of Biological Rhythms, 15: 317-326. (PDF)

Winter and summer outdoor light exposure in women with and without seasonal affective disorder. (2000)

Graw, P., Recker, S., Sand, L., Kräuchi, K. & Wirz-Justice, A.
Journal of Affective Disorders, 56: 163-169. (PDF)

Actigraphy to measure day structure as a therapeutic variable in the treatment of schizophrenic patients. (2000)

Haug, H.-J., Wirz-Justice, A. & Rössler, W.
Acta Psychiatrica Scandinavica, 102: 91-95.

Serum iron and ferritin in acute neuroleptic akathisia. (2000)

Hofmann, M., Seifritz, E., Botschev, C., Kräuchi, K., Müller-Spahn, F.
Psychiatry Res. 93: 201-207. (PDF)

Alzheimer's disease, depression and normal ageing: merit of simple psychomotor and visuospatial tasks. (2000)

Hofmann, M., Seifritz, E., Kräuchi, K., Hock, C., Hampel, H., Neugebauer, A., Müller-Spahn, F.
International Journal of Geriatric Psychiatry 15: 31-39.

Circadian rhythmicity: from basic science to clinical approach. (2000)

Illnerová, H., Borbély, A.A., Wirz-Justice, A. & Prasko, J.
Z. Ambler, S. Nevsimalova, Z. Kadanka, P.M.Rossini (Eds.) Clinical Neurophysiology at the Beginning of the 21st Century (Supplements to Clinical Neurophysiology Vol 53), Elsevier, pp.339-347.

A functional link between distal vasodilation and sleep onset latency? (2000)

Kräuchi, K., Cajochen, C., Werth, E. & Wirz-Justice A.
American Journal of Physiology, 278: R741-R748. (PDF)

Haloperidol disrupts, clozapine reinstates the circadian rest-activity cycle in a patient with early-onset Alzheimer�s disease. (2000)

Wirz-Justice, A., Werth, E., Savaskan, E., Knoblauch, V. Fontana Gasio, P. & Müller-Spahn, F.
Alzheimer Disease and Associated Disorders, 14: 212-215. (PDF)

Lichttherapie. (2000)

Wirz-Justice, A. & Graw, P.
Therapeutische Umschau, 57: 71-75.

1999

ELISA-quanitation of phosphorylated tau protein in the Alzheimer's desease brain. (1999)

Herrmann M, Golombowski S, Kräuchi K, Frey P, Mourton-Gilles C, Hulette C, Rosenberg C, Müller-Spahn F, Hock C.
Eur Neurol 42(4):205-10. (PDF)

Warm feet promote the rapid onset of sleep. (1999)

Kräuchi, K., Cajochen, C., Werth, E. & Wirz-Justice A.
Nature, 401: 36-37. (PDF)

Accelerated post-glucose glycaemia and altered alliesthesia test in seasonal affective disorder. (1999)

Kräuchi, K., Keller, U., Leonhardt, G., Brunner, D.P., van der Velde, P., Haug, H.-J. & Wirz-Justice A.
Journal of Affective Disorders, 53: 23-26. (PDF)

Melatonin and phase shifting. In: M. F. Holick and E.G. Jung (Eds.) Biologic Effects of Light 1998 (1999)

Wirz-Justice, A.
Kluwer Academic Publishers, Boston, pp.383-388.

An open trial of light therapy in hospitalised major depression. (1999)

Wirz-Justice, A., Graw, P., Röösli, H., Glauser, G. & Fleischhauer, J.
Journal of Affective Disorders, 52: 291-292. (PDF)

Sleep deprivation in depression: what do we know, where do we go? (1999)

Wirz-Justice, A. & Van den Hoofdakker, R.H.
Biological Psychiatry, (Invited Review) 46: 445-453. (PDF)

A rapid-cycling bipolar patient treated with long nights, bedrest, and light. (1999)

Wirz-Justice, A., Quinto, C., Cajochen, C., Werth, E. & Hock, C.
Biological Psychiatry, 45: 1075-1077. (PDF)

1998

Evening administration of melatonin and bright light: interactions on the EEG during sleep and wakefulness. (1998)

Cajochen, C., Kräuchi, K., Danilenko, K.V. & Wirz-Justice, A.
Journal of Sleep Research, 7: 145-157. (PDF)

Sleep deprivation response in seasonal affective disorder during a 40-hour constant routine. (1998)

Graw, P., Haug, H.-J., Leonhardt, G. & Wirz-Justice, A.
Journal of Affective Disorders, 48: 69-74. (PDF)

Circadian and homeostatic regulation of core body temperature and alertness in humans: what is the role of melatonin? (1998)

Kräuchi, K., Cajochen, C. & Wirz-Justice, A.
K.-I. Honma and S. Honma (Eds.), Circadian Clocks and Entrainment, Hokkaido University Press, Sapporo, 7: 131-146.

Die Biologische Uhr. (1998)

Roenneberg, T. & Wirz-Justice, A.
P. Onori, L. Jenny (Eds.) Zeit für Zeit, MGU Reihe, Band 3, Verlag des Kantons Baselland, 29-41.

Why is sleep deprivation an orphan drug? (1998)

Wirz-Justice, A.
Psychiatry Research, 81: 281-282. (PDF)

Beginning to see the light. (Invited Commentary) (1998)

Wirz-Justice, A.
Archives of General Psychiatry, 55: 861-862. (PDF)

Circadian functions and clinical applications of dawn simulation (1998)

Wirz-Justice, A., Terman, M., Terman, J.S., Boulos, Z., Remé, C.E. & Danilenko, K.V.
Y. Touitou (Ed.), Biological Clocks. Mechanisms and Applications. Elsevier Science, Amsterdam,189-194.

Lichttherapie. (1998)

Zulley, J. & Wirz-Justice, A. (Eds.)
S. Roderer Verlag, Regensburg. 3e revidierte Edition.

1997

Homeostatic versus circadian effects of melatonin on thermoregulation in humans. (1997)

Cagnacci, A., Kräuchi, K., Wirz-Justice, A. & Volpe, A
Journal of Biological Rhythms, 12: 509-517.

The acute soporific action of daytime melatonin administration: effects on waking EEG power density and alertness. (1997)

Cajochen, C., Kräuchi, K. & Wirz-Justice A.
Journal of Biological Rhythms, 12: 636- 643.

Melatonin and S-20098 phase advance REM sleep propensity and the wake-up threshold without modifying NREM-sleep homeostasis. (1997)

Cajochen, C., Kräuchi, K., Möri, D., Graw, P., & Wirz-Justice, A.
American Journal of Physiology, 272: R1189-R1196. (PDF)

Melatonin and the circadian regulation of sleep initiation, consolidation, structure and the sleep EEG. (1997)

Dijk, D.-J. & Cajochen, C.
Journal of Biological Rhythms, 12: 627-635.

Follow-up study of seasonal affective disorder in Switzerland. (1997)

Graw, P., Gisin, B. & Wirz-Justice A.
Psychopathology, 30: 208-214.

Melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature. (1997)

Kräuchi K., Cajochen C., Möri D., Graw P., & Wirz-Justice A.
American Journal of Physiology, 272: R1178-R1188. (PDF)

Eating style in seasonal affective disorder: who will gain weight in winter? (1997)

Kräuchi, K., Reich, S. & Wirz-Justice A.
Comprehensive Psychiatry, 38: 80-87.

A relationship between heat loss and sleepiness: effects of postural change and melatonin administration. (1997)

Kräuchi, K., Cajochen, C. & Wirz-Justice A.
Journal of Applied Physiology, 83: 134-139. (PDF)

The hypothermic effect of late evening melatonin does not block the phase delay induced by concurrent bright lightin human subjects. (1997)

Kräuchi, K., Cajochen, C., Danilenko, K.V. & Wirz-Justice A.
Neuroscience Letters, 232: 57-61.

Light therapy for depressive disorders: indications and efficacy. (1997)

Lam, R., Terman, M. & Wirz-Justice, A.
A. J. Rush (Ed.), Modern Problems in Pharmacopsychiatry: Clinical Decision Trees in the Pharma-cotherapy of Mood Disorders, 215-234.

A schizophrenic patient with an arrhythmic circadian rest-activity cycle. (1997)

Wirz-Justice A., Cajochen, C. & Nussbaum, P.
Psychiatry Research, 73: 83-90. (PDF)

Lithium decreases retinal sensitivity, but this is not cumulative with years of treatment. (1997)

Wirz-Justice, A., Remé, C.E., Prünte, A., Heinen, U., Graw, P. & Urner, U.
Biological Psychiatry, 41: 743-746. (PDF)