Dr. med. Corrado Garbazza
MD, PhD student, Clinical Research Physician
Publications
2020 |
Reichert, C F; Veitz, S; Bühler, M; Gruber, G; Deuring, G; S. S. Rehm, Rentsch K; Garbazza, C; Meyer, M; Slawik, H; Lin, Y -S; Weibel, J Wide awake at bedtime? The effects of caffeine on sleep and circadian timing in teenagers - a randomized crossover trial. Journal Article Biochemical Pharmacology, 2020. @article{Reichert2020, title = {Wide awake at bedtime? The effects of caffeine on sleep and circadian timing in teenagers - a randomized crossover trial.}, author = {C. F. Reichert and S. Veitz and M. Bühler and G. Gruber and G. Deuring and S. S. Rehm, K. Rentsch and C. Garbazza and M. Meyer and H. Slawik and Y.-S. Lin and J. Weibel}, doi = {https://doi.org/10.1016/j.bcp.2020.114283}, year = {2020}, date = {2020-10-15}, journal = {Biochemical Pharmacology}, abstract = {Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing sleep and circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent caffeine disturbs slow-wave sleep (SWS) and delays circadian timing in teenagers. Following a 6-day ambulatory phase of caffeine abstinence and fixed sleep-wake cycles, 18 male teenagers (14–17 years old) ingested 80 mg caffeine vs. placebo in the laboratory four hours prior to an electro-encephalographically (EEG) recorded nighttime sleep episode. Data were analyzed using both frequentist and Bayesian statistics. The analyses suggest that subjective sleepiness is reduced after caffeine compared to placebo. However, we did not observe a strong caffeine-induced reduction in subjective sleep quality or SWS, but rather a high inter-individual variability in caffeine-induced SWS changes. Exploratory analyses suggest that particularly those individuals with a higher level of SWS during placebo reduced SWS in response to caffeine. Regarding salivary melatonin onsets, caffeine-induced delays were not evident at group level, and only observed in participants exposed to a higher caffeine dose relative to individual bodyweight (i.e., a dose > 1.3 mg/kg). Together, the results suggest that 80 mg caffeine are sufficient to induce alertness at a subjective level. However, particularly teenagers with a strong need for deep sleep might pay for these subjective benefits by a loss of SWS during the night. Thus, caffeine-induced sleep-disruptions might change along with the maturation of sleep need.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing sleep and circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent caffeine disturbs slow-wave sleep (SWS) and delays circadian timing in teenagers. Following a 6-day ambulatory phase of caffeine abstinence and fixed sleep-wake cycles, 18 male teenagers (14–17 years old) ingested 80 mg caffeine vs. placebo in the laboratory four hours prior to an electro-encephalographically (EEG) recorded nighttime sleep episode. Data were analyzed using both frequentist and Bayesian statistics. The analyses suggest that subjective sleepiness is reduced after caffeine compared to placebo. However, we did not observe a strong caffeine-induced reduction in subjective sleep quality or SWS, but rather a high inter-individual variability in caffeine-induced SWS changes. Exploratory analyses suggest that particularly those individuals with a higher level of SWS during placebo reduced SWS in response to caffeine. Regarding salivary melatonin onsets, caffeine-induced delays were not evident at group level, and only observed in participants exposed to a higher caffeine dose relative to individual bodyweight (i.e., a dose > 1.3 mg/kg). Together, the results suggest that 80 mg caffeine are sufficient to induce alertness at a subjective level. However, particularly teenagers with a strong need for deep sleep might pay for these subjective benefits by a loss of SWS during the night. Thus, caffeine-induced sleep-disruptions might change along with the maturation of sleep need. |
Weibel, J; Lin, Y -S; Landolt, H -P; Garbazza, C; Kolodyazhniy, V; Kistler, J; Rehm, S; Rentsch, K; Borgwardt, S; Cajochen, C; Reichert, C F Caffeine-dependent changes of sleep-wake regulation: Evidence foradaptation after repeated intake Journal Article Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020. @article{Weibel2020, title = {Caffeine-dependent changes of sleep-wake regulation: Evidence foradaptation after repeated intake}, author = {J. Weibel and Y.-S. Lin and H.-P. Landolt and C. Garbazza and V. Kolodyazhniy and J. Kistler and S. Rehm and K. Rentsch and S. Borgwardt and C. Cajochen and C. F. Reichert }, url = {http://www.chronobiology.ch/1-s2-0-s0278584619304798-main-2/}, doi = {10.1016/j.pnpbp.2019.109851 }, year = {2020}, date = {2020-04-20}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, abstract = {Background: Circadian and sleep-homeostatic mechanisms regulate timing and quality of wakefulness. To enhance wakefulness, daily consumption of caffeine in the morning and afternoon is highly common. However, the effects of such a regular intake pattern on circadian sleep-wake regulation are unknown. Thus, we investigated if daily daytime caffeine intake and caffeine withdrawal affect circadian rhythms and wake-promotion in habitual consumers. Methods: Twenty male young volunteers participated in a randomised, double-blind, within-subject study with three conditions: i) caffeine (150 mg 3 x daily for 10 days), ii) placebo (3 x daily for 10 days) and iii) withdrawal (150 mg caffeine 3 x daily for eight days, followed by a switch to placebo for two days). Starting on day nine of treatment, salivary melatonin and cortisol, evening nap sleep as well as sleepiness and vigilance performance throughout day and night were quantified during 43 h in an in-laboratory, light and posture-controlled protocol. Results: Neither the time course of melatonin (i.e. onset, amplitude or area under the curve) nor the time course of cortisol was significantly affected by caffeine or withdrawal. During withdrawal, however, volunteers reported increased sleepiness, showed more attentional lapses as well as polysomnography-derived markers of elevated sleep propensity in the late evening compared to both the placebo and caffeine condition. Conclusions: The typical pattern of caffeine intake with consumption in both the morning and afternoon hours may not necessarily result in a circadian phase shift in the evening nor lead to clear-cut benefits in alertness. The time-of-day independent effects of caffeine withdrawal on evening nap sleep, sleepiness and performance suggest an adaptation to the substance, presumably in the homeostatic aspect of sleep-wake regulation.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: Circadian and sleep-homeostatic mechanisms regulate timing and quality of wakefulness. To enhance wakefulness, daily consumption of caffeine in the morning and afternoon is highly common. However, the effects of such a regular intake pattern on circadian sleep-wake regulation are unknown. Thus, we investigated if daily daytime caffeine intake and caffeine withdrawal affect circadian rhythms and wake-promotion in habitual consumers. Methods: Twenty male young volunteers participated in a randomised, double-blind, within-subject study with three conditions: i) caffeine (150 mg 3 x daily for 10 days), ii) placebo (3 x daily for 10 days) and iii) withdrawal (150 mg caffeine 3 x daily for eight days, followed by a switch to placebo for two days). Starting on day nine of treatment, salivary melatonin and cortisol, evening nap sleep as well as sleepiness and vigilance performance throughout day and night were quantified during 43 h in an in-laboratory, light and posture-controlled protocol. Results: Neither the time course of melatonin (i.e. onset, amplitude or area under the curve) nor the time course of cortisol was significantly affected by caffeine or withdrawal. During withdrawal, however, volunteers reported increased sleepiness, showed more attentional lapses as well as polysomnography-derived markers of elevated sleep propensity in the late evening compared to both the placebo and caffeine condition. Conclusions: The typical pattern of caffeine intake with consumption in both the morning and afternoon hours may not necessarily result in a circadian phase shift in the evening nor lead to clear-cut benefits in alertness. The time-of-day independent effects of caffeine withdrawal on evening nap sleep, sleepiness and performance suggest an adaptation to the substance, presumably in the homeostatic aspect of sleep-wake regulation. |
2019 |
Garbazza, C; Hackethal, S; Riccardi, S; Cajochen, C; Cicolin, A; D'Agostino, A; Cirignotta, F; Manconi, M Polysomnographic features of pregnancy: A systematic review Journal Article Sleep Med Rev., 2019. @article{Garbazza2019, title = {Polysomnographic features of pregnancy: A systematic review}, author = {C. Garbazza and S. Hackethal and S. Riccardi and C. Cajochen and A. Cicolin and A. D'Agostino and F. Cirignotta and M. Manconi}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/1-s2.0-S1087079219302175-main.pdf}, doi = {10.1016/j.smrv.2019.101249}, year = {2019}, date = {2019-12-05}, journal = {Sleep Med Rev.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Blume, C; Garbazza, C; Spitschan, M Effects of light on human circadian rhythms, sleep and mood Journal Article Somnologie Berl, 2019. @article{Blume2019, title = {Effects of light on human circadian rhythms, sleep and mood}, author = {C. Blume and C. Garbazza and M. Spitschan}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/EMS84169.pdf}, doi = {doi:10.1007/s11818-019-00215-x}, year = {2019}, date = {2019-09-18}, journal = {Somnologie Berl}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Cajochen, C; Freyburger, M; Basishvili, T; Garbazza, C; Rudzik, F; Renz, C; Kobayashi, K; Shirakawa, Y; Stefani, O; Weibel, J Effect of daylight LED on visual comfort, melatonin, mood, waking performance and sleep Journal Article 2019. @article{Cajochen2019, title = {Effect of daylight LED on visual comfort, melatonin, mood, waking performance and sleep}, author = {C. Cajochen and M. Freyburger and T. Basishvili and C. Garbazza and F. Rudzik and C. Renz and K. Kobayashi and Y. Shirakawa and O. Stefani and J. Weibel}, doi = {10.1177/1477153519828419}, year = {2019}, date = {2019-03-24}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2018 |
Garbazza, C; Manconi, M Management Strategies for Restless Legs Syndrome/Willis-Ekbom Disease During Pregnancy. Journal Article Sleep Medicine Clinics, pp. doi: 10.1016/j.jsmc.2018.05.001, 2018. @article{, title = {Management Strategies for Restless Legs Syndrome/Willis-Ekbom Disease During Pregnancy.}, author = {C. Garbazza and M. Manconi}, year = {2018}, date = {2018-09-13}, journal = {Sleep Medicine Clinics}, pages = {doi: 10.1016/j.jsmc.2018.05.001}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garbazza, C; Benedetti, F Genetic Factors Affecting Seasonality, Mood, and the Circadian Clock. Journal Article Frontiers in Endocrinology, pp. doi: 10.3389/fendo.2018.00481, 2018. @article{, title = {Genetic Factors Affecting Seasonality, Mood, and the Circadian Clock.}, author = {C. Garbazza and F. Benedetti}, url = {http://www.chronobiology.ch/wp-content/uploads/2018/09/fendo-09-00481-1.pdf}, year = {2018}, date = {2018-08-23}, journal = {Frontiers in Endocrinology}, pages = {doi: 10.3389/fendo.2018.00481}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garbazza, C Non-24-Hour Sleep-Wake Disorder in Sighted Patients: Dealing With an Orphan Disease. Journal Article Journal of Clinical Sleep Medicine, pp. doi: 10.5664/jcsm.7304, 2018. @article{, title = {Non-24-Hour Sleep-Wake Disorder in Sighted Patients: Dealing With an Orphan Disease.}, author = {C. Garbazza}, url = {http://www.chronobiology.ch/wp-content/uploads/2018/09/Article.pdf}, year = {2018}, date = {2018-08-15}, journal = {Journal of Clinical Sleep Medicine}, pages = {doi: 10.5664/jcsm.7304}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Rudzik, F; Thiesse, L; Pieren, R; Wunderli, J M; Brink, M; Foraster, M; Héritier, H; Exe, I C; Garbazza, C; Vienneau, D; Probst-Hensch, N; Röösli, M; Cajochen, C Sleep spindle characteristics and arousability from nighttime transportation noise exposure in healthy young and older individuals. Journal Article Sleep, 41 (7), pp. doi: 10.1093/sleep/zsy077, 2018. @article{, title = {Sleep spindle characteristics and arousability from nighttime transportation noise exposure in healthy young and older individuals.}, author = {F. Rudzik and L. Thiesse and R. Pieren and J. M. Wunderli and M. Brink and M. Foraster and H. Héritier and I. C. Exe and C. Garbazza and D. Vienneau and N. Probst-Hensch and M. Röösli and C. Cajochen}, year = {2018}, date = {2018-07-01}, journal = {Sleep}, volume = {41}, number = {7}, pages = { doi: 10.1093/sleep/zsy077}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garbazza, C; Sauter, C; Paul, J; Kollek, J; Dujardin, C; Hackethal, S; Dorn, H; Peter, A; Hansen, M L; Manconi, M; Ferri, R; Danker-Hopfe, H Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder. Journal Article Frontiers in Psychiatry, pp. doi: 10.3389/fpsyt.2018.00179, 2018. @article{, title = {Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder.}, author = {C. Garbazza and C. Sauter and J. Paul and J. Kollek and C. Dujardin and S. Hackethal and H. Dorn and A. Peter and M.L. Hansen and M. Manconi and R. Ferri and H. Danker-Hopfe}, url = {http://www.chronobiology.ch/wp-content/uploads/2018/09/fpsyt-09-00179.pdf}, year = {2018}, date = {2018-05-04}, journal = {Frontiers in Psychiatry}, pages = {doi: 10.3389/fpsyt.2018.00179}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2017 |
Gabel, V; Reichert, C F; Maire, M; Schmidt, C; Schlangen, L J M; Kolodyazhniy, V; Garbazza, C; Cajochen, C; Viola, A U Scientific Reports, 7 (7620), pp. doi:doi:10.1038/s41598-017-07060-8, 2017. @article{, title = {Differential impact in young and older individuals of blue-enriched white light on circadian physiology and alertness during sustained wakefulness}, author = {V. Gabel and C. F. Reichert and M. Maire and C. Schmidt and L. J. M. Schlangen and V. Kolodyazhniy and C. Garbazza and C. Cajochen and A. U. Viola}, url = {https://www.nature.com/articles/s41598-017-07060-8.pdf}, year = {2017}, date = {2017-08-08}, journal = {Scientific Reports}, volume = {7}, number = {7620}, pages = {doi:doi:10.1038/s41598-017-07060-8}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2016 |
Baiardi, S; Cirignotta, F; Cicolin, A; Garbazza, C; D'Agostino, A; Gambini, O; Giordano, A; Canevini, M; Zambrelli, E; Marconi, A M; Mondini, S; Borgwardt, S; Cajochen, C; Rizzo, N; Manconi, M Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project Journal Article BMC Psychiatry, 16 , pp. doi:10.1186/s12888-016-1086-0, 2016. @article{, title = {Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project}, author = {S. Baiardi and F. Cirignotta and A. Cicolin and C. Garbazza and A. D'Agostino and O. Gambini and A. Giordano and M. Canevini and E. Zambrelli and A. M. Marconi and S. Mondini and S. Borgwardt and C. Cajochen and N. Rizzo and M. Manconi}, url = {http://www.chronobiology.ch/wp-content/uploads/2016/11/art3A10.11862Fs12888-016-1086-0.pdf}, year = {2016}, date = {2016-11-04}, journal = {BMC Psychiatry}, volume = {16}, pages = {doi:10.1186/s12888-016-1086-0}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garbazza, C; Bromundt, V; Eckert, A; Brunner, D P; Meier, F; Hackethal, S; Cajochen, C Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study Journal Article Front Neurol. 2016 Feb 29;7:17 doi: 10.3389/fneur.2016.00017, 2016. @article{, title = {Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study}, author = {C. Garbazza and V. Bromundt and A. Eckert and D.P. Brunner and F. Meier and S. Hackethal and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2016/06/fneur-07-00017-3.pdf}, year = {2016}, date = {2016-02-29}, journal = {Front Neurol. 2016 Feb 29;7:17 doi: 10.3389/fneur.2016.00017}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2015 |
vanderLely, S; Frey, S; Garbazza, C; Wirz-Justice, A; Jenni, O G; Steiner, R; Wolf, S; Cajochen, C; Bromundt, V; Schmidt, C Blue blocker glasses as a countermeasure for alerting effects of evening light-emitting diode screen exposure in male teenagers Journal Article J Adolesc Health, doi: 10.1016/j.jadohealth.2014.08.002, 56(1) , pp. 113-119, 2015. @article{, title = {Blue blocker glasses as a countermeasure for alerting effects of evening light-emitting diode screen exposure in male teenagers}, author = {S. vanderLely and S. Frey and C. Garbazza and A. Wirz-Justice and O. G. Jenni and R. Steiner and S. Wolf and C. Cajochen and V. Bromundt and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2015/08/11.pdf}, year = {2015}, date = {2015-08-20}, journal = {J Adolesc Health, doi: 10.1016/j.jadohealth.2014.08.002}, volume = {56(1)}, pages = {113-119}, keywords = {}, pubstate = {published}, tppubtype = {article} } |