Prof. Dr. Christian Cajochen
Head Centre for Chronobiology
Prof. Christian Cajochen is heading the Centre for Chronobiology at the University of Basel. He received his PhD in natural sciences from the ETH in Zürich, Switzerland, followed by a 3-y postdoctoral stay at the Harvard Medical School in Boston, USA. His major research interests include investigative work on the influence of light on human cognition, circadian rhythms and sleep, circadian related disturbances in psychiatric disorders, and age-related changes in the circadian regulation of sleep and neurobehavioral performance. He has held a number of honours and has authored more than 200 original papers and reviews in his career.
Publications
2021 |
Blume, C; Cajochen, C ‘SleepCycles’ package for R - A free software tool for the detection of sleep cycles from sleep staging Journal Article MethodsX, 2021. @article{Blume2021, title = {‘SleepCycles’ package for R - A free software tool for the detection of sleep cycles from sleep staging}, author = {C. Blume and C. Cajochen}, doi = {https://doi.org/10.1016/j.mex.2021.101318}, year = {2021}, date = {2021-04-06}, journal = {MethodsX}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Weibel, J; Lin, Y -S; Landolt, H -P; Kistler, J; Rehm, S; Rentsch, K; Slawik, H; Borgwardt, S; Cajochen, C; Reichert, C F The impact of daily caffeine intake on nighttime sleep in young adult men Journal Article Scientific Reports, 2021. @article{Weibel2021, title = {The impact of daily caffeine intake on nighttime sleep in young adult men}, author = {J. Weibel and Y.-S. Lin and H.-P. Landolt and J. Kistler and S. Rehm and K. Rentsch and H. Slawik and S. Borgwardt and C. Cajochen and C. F. Reichert }, url = {http://www.chronobiology.ch/weibel-2021-caffeine-sleep/}, doi = {10.1038/s41598-021-84088-x}, year = {2021}, date = {2021-02-25}, journal = {Scientific Reports}, abstract = {Acute caffeine intake can delay sleep initiation and reduce sleep intensity, particularly when consumed in the evening. However, it is not clear whether these sleep disturbances disappear when caffeine is continuously consumed during daytime, which is common for most coffee drinkers. To address this question, we investigated the sleep of twenty male young habitual caffeine consumers during a double‑blind, randomized, crossover study including three 10‑day conditions: caffeine (3 × 150 mg caffeine daily), withdrawal (3 × 150 mg caffeine for 8 days, then switch to placebo), and placebo (3 × placebo daily). After 9 days of continuous treatment, electroencephalographically (EEG)‑derived sleep structure and intensity were recorded during a scheduled 8‑h nighttime sleep episode starting 8 (caffeine condition) and 15 h (withdrawal condition) after the last caffeine intake. Upon scheduled wake‑up time, subjective sleep quality and caffeine withdrawal symptoms were assessed. Unexpectedly, neither polysomnography‑derived total sleep time, sleep latency, sleep architecture nor subjective sleep quality differed among placebo, caffeine, and withdrawal conditions. Nevertheless, EEG power density in the sigma frequencies (12–16 Hz) during non‑rapid eye movement sleep was reduced in both caffeine and withdrawal conditions when compared to placebo. These results indicate that daily caffeine intake in the morning and afternoon hours does not strongly impair nighttime sleep structure nor subjective sleep quality in healthy good sleepers who regularly consume caffeine. The reduced EEG power density in the sigma range might represent early signs of overnight withdrawal from the continuous presence of the stimulant during the day.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Acute caffeine intake can delay sleep initiation and reduce sleep intensity, particularly when consumed in the evening. However, it is not clear whether these sleep disturbances disappear when caffeine is continuously consumed during daytime, which is common for most coffee drinkers. To address this question, we investigated the sleep of twenty male young habitual caffeine consumers during a double‑blind, randomized, crossover study including three 10‑day conditions: caffeine (3 × 150 mg caffeine daily), withdrawal (3 × 150 mg caffeine for 8 days, then switch to placebo), and placebo (3 × placebo daily). After 9 days of continuous treatment, electroencephalographically (EEG)‑derived sleep structure and intensity were recorded during a scheduled 8‑h nighttime sleep episode starting 8 (caffeine condition) and 15 h (withdrawal condition) after the last caffeine intake. Upon scheduled wake‑up time, subjective sleep quality and caffeine withdrawal symptoms were assessed. Unexpectedly, neither polysomnography‑derived total sleep time, sleep latency, sleep architecture nor subjective sleep quality differed among placebo, caffeine, and withdrawal conditions. Nevertheless, EEG power density in the sigma frequencies (12–16 Hz) during non‑rapid eye movement sleep was reduced in both caffeine and withdrawal conditions when compared to placebo. These results indicate that daily caffeine intake in the morning and afternoon hours does not strongly impair nighttime sleep structure nor subjective sleep quality in healthy good sleepers who regularly consume caffeine. The reduced EEG power density in the sigma range might represent early signs of overnight withdrawal from the continuous presence of the stimulant during the day. |
Lin, Y -S; Weibel, J; Landolt, H; Santini, F; Meyer, M; Brunmair, J; Meyer-Menches, S; gerner, C; Borgwardt, S; Cajochen, C; Reichert, C F Cerebral Cortex, 2021. @article{Lin2021, title = {Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial }, author = { Y.-S. Lin and J. Weibel and H. Landolt and F. Santini and M. Meyer and J. Brunmair and S. Meyer-Menches and C. gerner and S. Borgwardt and C. Cajochen and C. F. Reichert}, url = {http://www.chronobiology.ch/lin_2021_cc_acc_uncorrect/}, doi = {doi.org/10.1093/cercor/bhab005}, year = {2021}, date = {2021-02-15}, journal = {Cerebral Cortex}, abstract = {Caffeine is commonly used to combat high sleep pressure on a daily basis. However, interference with sleep–wake regulation could disturb neural homeostasis and insufficient sleep could lead to alterations in human gray matter. Hence, in this double-blind, randomized, cross-over study, we examined the impact of 10-day caffeine (3 × 150 mg/day) on human gray matter volumes (GMVs) and cerebral blood flow (CBF) by fMRI MP-RAGE and arterial spin-labeling sequences in 20 habitual caffeine consumers, compared with 10-day placebo (3 × 150 mg/day). Sleep pressure was quantified by electroencephalographic slow-wave activity (SWA) in the previous nighttime sleep. Nonparametric voxel-based analyses revealed a significant reduction in GMV in the medial temporal lobe (mTL) after 10 days of caffeine intake compared with 10 days of placebo, voxel-wisely adjusted for CBF considering the decreased perfusion after caffeine intake compared with placebo. Larger GMV reductions were associated with higher individual concentrations of caffeine and paraxanthine. Sleep SWA was, however, neither different between conditions nor associated with caffeine-induced GMV reductions. Therefore, the data do not suggest a link between sleep depth during daily caffeine intake and changes in brain morphology. In conclusion, daily caffeine intake might induce neural plasticity in the mTL depending on individual metabolic processes.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Caffeine is commonly used to combat high sleep pressure on a daily basis. However, interference with sleep–wake regulation could disturb neural homeostasis and insufficient sleep could lead to alterations in human gray matter. Hence, in this double-blind, randomized, cross-over study, we examined the impact of 10-day caffeine (3 × 150 mg/day) on human gray matter volumes (GMVs) and cerebral blood flow (CBF) by fMRI MP-RAGE and arterial spin-labeling sequences in 20 habitual caffeine consumers, compared with 10-day placebo (3 × 150 mg/day). Sleep pressure was quantified by electroencephalographic slow-wave activity (SWA) in the previous nighttime sleep. Nonparametric voxel-based analyses revealed a significant reduction in GMV in the medial temporal lobe (mTL) after 10 days of caffeine intake compared with 10 days of placebo, voxel-wisely adjusted for CBF considering the decreased perfusion after caffeine intake compared with placebo. Larger GMV reductions were associated with higher individual concentrations of caffeine and paraxanthine. Sleep SWA was, however, neither different between conditions nor associated with caffeine-induced GMV reductions. Therefore, the data do not suggest a link between sleep depth during daily caffeine intake and changes in brain morphology. In conclusion, daily caffeine intake might induce neural plasticity in the mTL depending on individual metabolic processes. |
2020 |
Blume, C; Schmidt, Marlene H; Cajochen, C Effects of the COVID-19 lockdown on human sleep and rest-activity rhythms Journal Article Current Biology, 2020. @article{Blume2020b, title = {Effects of the COVID-19 lockdown on human sleep and rest-activity rhythms}, author = {C. Blume and Marlene H. Schmidt and C. Cajochen}, doi = {https://doi.org/10.1016/j.cub.2020.06.021}, year = {2020}, date = {2020-06-10}, journal = {Current Biology}, abstract = {In modern societies, human rest-activity rhythms and sleep result from the tensions and dynamics between the conflicting poles of external social time (e.g., work hours and leisure activities) and an individual’s internal biological time. A mismatch between the two has been suggested to induce ‘social jetlag’ [SJL; 1] and ‘social sleep restriction’ (SSR), that is, shifts in sleep timing and differences in sleep duration between work days and free days. Social jetlag [2, 3] and sleep restrictions [4] have repeatedly been associated with negative consequences on health, mental wellbeing, and performance. In a large-scale quasi-experimental design, we investigated the effects of the phase with the strictest COVID-19 restrictions on the relationship between social and biological rhythms as well as sleep during a six-week period (mid-March until end of April 2020) in three European societies (Austria, Germany, Switzerland). We found that, on one hand, the restrictions reduced the mismatch between external (social) and internal (biological) sleep-wake timing, as indexed by significant reductions in SJL and SSR, with a concomitant increase in sleep duration. Sleep quality on the other hand was slightly reduced. The improved individual sleep-wake timing can presumably be attributed to an increased flexibility of social schedules, for instance due to more work being accomplished from home. However, this unprecedented situation also led to a significant increase in self-perceived burden, which was attendant to the decrease in sleep quality. These adverse effects may be alleviated by exposure to natural daylight as well as physical exercising.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In modern societies, human rest-activity rhythms and sleep result from the tensions and dynamics between the conflicting poles of external social time (e.g., work hours and leisure activities) and an individual’s internal biological time. A mismatch between the two has been suggested to induce ‘social jetlag’ [SJL; 1] and ‘social sleep restriction’ (SSR), that is, shifts in sleep timing and differences in sleep duration between work days and free days. Social jetlag [2, 3] and sleep restrictions [4] have repeatedly been associated with negative consequences on health, mental wellbeing, and performance. In a large-scale quasi-experimental design, we investigated the effects of the phase with the strictest COVID-19 restrictions on the relationship between social and biological rhythms as well as sleep during a six-week period (mid-March until end of April 2020) in three European societies (Austria, Germany, Switzerland). We found that, on one hand, the restrictions reduced the mismatch between external (social) and internal (biological) sleep-wake timing, as indexed by significant reductions in SJL and SSR, with a concomitant increase in sleep duration. Sleep quality on the other hand was slightly reduced. The improved individual sleep-wake timing can presumably be attributed to an increased flexibility of social schedules, for instance due to more work being accomplished from home. However, this unprecedented situation also led to a significant increase in self-perceived burden, which was attendant to the decrease in sleep quality. These adverse effects may be alleviated by exposure to natural daylight as well as physical exercising. |
Eze, I C; Jeong, A; Schaffner, E; Rezwan, F I; Ghantous, A; Foraster, M; Vienneau, D; F, Kronenberg F; Herceg, Z; Vineis, P; Brink, M; Wunderli, J M; Schindler, C; Cajochen, C; M, Röösli M; Holloway, J W; Imboden, M; Probst-Hensch, N Environ Health Perspect, 128 (6), pp. 67003, 2020. @article{Eze2020, title = {Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study}, author = {I. C. Eze and A. Jeong and E. Schaffner and F. I. Rezwan and A. Ghantous and M. Foraster and D. Vienneau and F. Kronenberg F and Z. Herceg and P. Vineis and M. Brink and J. M. Wunderli and C. Schindler and C. Cajochen and M. Röösli M and J. W. Holloway and M. Imboden and N. Probst-Hensch}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/06/EHP6174.pdf}, year = {2020}, date = {2020-06-01}, journal = {Environ Health Perspect}, volume = {128}, number = {6}, pages = {67003}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Hollinger, A; von Felten, S; Sutter, R; Huber, J; Tran, F; Reinhold, S; Abdelhamid, S; Todorov, A; Gebhard, C E; Cajochen, C; Steiner, L A; Siegemund, M BMJ Open, 2020. @article{Hollinger2020, title = {Study Protocol for a Prospective Randomised Double-Blind Placebo-Controlled Clinical Trial Investigating a Better Outcome With Melatonin Compared to Placebo Administered to Normalize Sleep-Wake Cycle and Treat Hypoactive ICU Delirium: The Basel BOMP-AID Study}, author = {A. Hollinger and S. von Felten and R. Sutter and J. Huber and F. Tran and S. Reinhold and S. Abdelhamid and A. Todorov and C. E. Gebhard and C. Cajochen and L. A Steiner and M. Siegemund}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/05/e034873.full_.pdf}, doi = {10.1136/bmjopen-2019-034873}, year = {2020}, date = {2020-04-30}, journal = {BMJ Open}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Weibel, J; Lin, Y -S; Landolt, H -P; Garbazza, C; Kolodyazhniy, V; Kistler, J; Rehm, S; Rentsch, K; Borgwardt, S; Cajochen, C; Reichert, C F Caffeine-dependent changes of sleep-wake regulation: Evidence foradaptation after repeated intake Journal Article Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020. @article{Weibel2020, title = {Caffeine-dependent changes of sleep-wake regulation: Evidence foradaptation after repeated intake}, author = {J. Weibel and Y.-S. Lin and H.-P. Landolt and C. Garbazza and V. Kolodyazhniy and J. Kistler and S. Rehm and K. Rentsch and S. Borgwardt and C. Cajochen and C. F. Reichert }, url = {http://www.chronobiology.ch/1-s2-0-s0278584619304798-main-2/}, doi = {10.1016/j.pnpbp.2019.109851 }, year = {2020}, date = {2020-04-20}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, abstract = {Background: Circadian and sleep-homeostatic mechanisms regulate timing and quality of wakefulness. To enhance wakefulness, daily consumption of caffeine in the morning and afternoon is highly common. However, the effects of such a regular intake pattern on circadian sleep-wake regulation are unknown. Thus, we investigated if daily daytime caffeine intake and caffeine withdrawal affect circadian rhythms and wake-promotion in habitual consumers. Methods: Twenty male young volunteers participated in a randomised, double-blind, within-subject study with three conditions: i) caffeine (150 mg 3 x daily for 10 days), ii) placebo (3 x daily for 10 days) and iii) withdrawal (150 mg caffeine 3 x daily for eight days, followed by a switch to placebo for two days). Starting on day nine of treatment, salivary melatonin and cortisol, evening nap sleep as well as sleepiness and vigilance performance throughout day and night were quantified during 43 h in an in-laboratory, light and posture-controlled protocol. Results: Neither the time course of melatonin (i.e. onset, amplitude or area under the curve) nor the time course of cortisol was significantly affected by caffeine or withdrawal. During withdrawal, however, volunteers reported increased sleepiness, showed more attentional lapses as well as polysomnography-derived markers of elevated sleep propensity in the late evening compared to both the placebo and caffeine condition. Conclusions: The typical pattern of caffeine intake with consumption in both the morning and afternoon hours may not necessarily result in a circadian phase shift in the evening nor lead to clear-cut benefits in alertness. The time-of-day independent effects of caffeine withdrawal on evening nap sleep, sleepiness and performance suggest an adaptation to the substance, presumably in the homeostatic aspect of sleep-wake regulation.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: Circadian and sleep-homeostatic mechanisms regulate timing and quality of wakefulness. To enhance wakefulness, daily consumption of caffeine in the morning and afternoon is highly common. However, the effects of such a regular intake pattern on circadian sleep-wake regulation are unknown. Thus, we investigated if daily daytime caffeine intake and caffeine withdrawal affect circadian rhythms and wake-promotion in habitual consumers. Methods: Twenty male young volunteers participated in a randomised, double-blind, within-subject study with three conditions: i) caffeine (150 mg 3 x daily for 10 days), ii) placebo (3 x daily for 10 days) and iii) withdrawal (150 mg caffeine 3 x daily for eight days, followed by a switch to placebo for two days). Starting on day nine of treatment, salivary melatonin and cortisol, evening nap sleep as well as sleepiness and vigilance performance throughout day and night were quantified during 43 h in an in-laboratory, light and posture-controlled protocol. Results: Neither the time course of melatonin (i.e. onset, amplitude or area under the curve) nor the time course of cortisol was significantly affected by caffeine or withdrawal. During withdrawal, however, volunteers reported increased sleepiness, showed more attentional lapses as well as polysomnography-derived markers of elevated sleep propensity in the late evening compared to both the placebo and caffeine condition. Conclusions: The typical pattern of caffeine intake with consumption in both the morning and afternoon hours may not necessarily result in a circadian phase shift in the evening nor lead to clear-cut benefits in alertness. The time-of-day independent effects of caffeine withdrawal on evening nap sleep, sleepiness and performance suggest an adaptation to the substance, presumably in the homeostatic aspect of sleep-wake regulation. |
Chellappa, S L; Bromundt, V; Frey, S; Schlote, T; Goldblum, D; Cajochen, C; Reichert, C F Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults Journal Article 2020. @article{Chellappa2020, title = {Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults}, author = {S. L. Chellappa and V. Bromundt and S. Frey and T. Schlote and D. Goldblum and C. Cajochen and C. F. Reichert}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/04/Chellappa-et-al.-JSR_2020.pdf}, doi = {10.1111/jsr.13043}, year = {2020}, date = {2020-04-14}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Rudzik, F; Thiesse, L; Pieren, R; Héritier, H; Eze, I C; Foraster, M; Vienneau, D; Brink, M; Wunderli, J M; Probst-Hensch, N; Röösli, M; Fulda, S; Cajochen, C Ultradian Modulation of Cortical Arousals During Sleep: Effects of Age and Exposure to Nighttime Transportation Noise Journal Article Sleep, 2020. @article{Rudzik2020, title = {Ultradian Modulation of Cortical Arousals During Sleep: Effects of Age and Exposure to Nighttime Transportation Noise}, author = {F. Rudzik and L. Thiesse and R. Pieren and H. Héritier and I. C Eze and M. Foraster and D. Vienneau and M. Brink and J. M. Wunderli and N. Probst-Hensch and M. Röösli and S. Fulda and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/05/zsz324.pdf}, doi = {10.1093/sleep/zsz324}, year = {2020}, date = {2020-02-26}, journal = {Sleep}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2019 |
Cajochen, C; Reichert, C; Maire, M; Schlangen, L J M; Schmidt, C; Viola, A U; Gabel, V Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness Journal Article Clocks & Sleep, 2019. @article{Cajochen2019b, title = {Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness}, author = {C. Cajochen and C. Reichert and M. Maire and L. J. M. Schlangen and C. Schmidt and A. U. Viola and V. Gabel}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/05/clockssleep-01-00040-v2.pdf}, doi = {10.3390/clockssleep1040040}, year = {2019}, date = {2019-12-11}, journal = {Clocks & Sleep}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garbazza, C; Hackethal, S; Riccardi, S; Cajochen, C; Cicolin, A; D'Agostino, A; Cirignotta, F; Manconi, M Polysomnographic features of pregnancy: A systematic review Journal Article Sleep Med Rev., 2019. @article{Garbazza2019, title = {Polysomnographic features of pregnancy: A systematic review}, author = {C. Garbazza and S. Hackethal and S. Riccardi and C. Cajochen and A. Cicolin and A. D'Agostino and F. Cirignotta and M. Manconi}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/1-s2.0-S1087079219302175-main.pdf}, doi = {10.1016/j.smrv.2019.101249}, year = {2019}, date = {2019-12-05}, journal = {Sleep Med Rev.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Spitschan, M; Lazar, R; Cajochen, C Visual and non-visual properties of filters manipulating short-wavelength light Journal Article Ophthalmic Physiol Opt, 2019. @article{Spitschan2019, title = {Visual and non-visual properties of filters manipulating short-wavelength light}, author = {M. Spitschan and R. Lazar and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/Spitschan_et_al-2019-Ophthalmic_and_Physiological_Optics-1.pdf}, doi = {10.1111/opo.12648}, year = {2019}, date = {2019-11-01}, journal = {Ophthalmic Physiol Opt}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Spitschan, M; Cajochen, C Binocular facilitation in light-mediated melatonin suppression? Journal Article J Pineal Res, 2019. @article{Spitschan2019b, title = {Binocular facilitation in light-mediated melatonin suppression?}, author = {M. Spitschan and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/Spitschan_et_al-2019-Journal_of_Pineal_Research.pdf}, doi = {10.1111/jpi.12602}, year = {2019}, date = {2019-11-01}, journal = {J Pineal Res}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Brink, M; Schäffer, B; Vienneau, D; Pieren, R; Foraster, M; Eze, I C; Rudzik, F; Thiesse, L; Cajochen, C; Probst-Hensch, N; Röösli, M; JM24., Wunderli J M Self-Reported Sleep Disturbance from Road, Rail and Aircraft Noise: Exposure-Response Relationships and Effect Modifiers in the SiRENE Study Journal Article Environ Int, 2019. @article{Brink2019b, title = {Self-Reported Sleep Disturbance from Road, Rail and Aircraft Noise: Exposure-Response Relationships and Effect Modifiers in the SiRENE Study}, author = {M. Brink and B. Schäffer and D. Vienneau and R. Pieren and M. Foraster and I. C. Eze and F. Rudzik and L. Thiesse and C. Cajochen and N. Probst-Hensch and M. Röösli and J. M. Wunderli JM24.}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/ijerph-16-04186-v3.pdf}, doi = {10.3390/ijerph16214186}, year = {2019}, date = {2019-10-29}, journal = {Environ Int}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Röösli, M; Brink, M; Rudzik, F; Cajochen, C; Ragettli, M S; Flückiger, B; Pieren, R; Vienneau, D; Wunderli, J -M Associations of Various Nighttime Noise Exposure Indicators with Objective Sleep Efficiency and Self-Reported Sleep Quality: A Field Study Journal Article Environ Int, 2019. @article{Röösli2019, title = {Associations of Various Nighttime Noise Exposure Indicators with Objective Sleep Efficiency and Self-Reported Sleep Quality: A Field Study}, author = {M. Röösli and M. Brink and F. Rudzik and C. Cajochen and M. S. Ragettli and B. Flückiger and R. Pieren and D. Vienneau and J.-M. Wunderli}, url = {http://www.chronobiology.ch/wp-content/uploads/2020/01/ijerph-16-03790.pdf}, doi = {10.3390/ijerph16203790}, year = {2019}, date = {2019-10-09}, journal = {Environ Int}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Gaig, C; Iranzo, A; Cajochen, C; Vilaseca, I; Embid, C; Dalmau, J; Graus, F; Santamaria, J Characterization of the sleep disorder of anti-IgLON5 disease. Journal Article Sleep, 2019. @article{Gaig2019, title = {Characterization of the sleep disorder of anti-IgLON5 disease.}, author = {C. Gaig and A. Iranzo and C. Cajochen and I. Vilaseca and C. Embid and J. Dalmau and F. Graus and J. Santamaria}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/06/zsz133.pdf}, doi = {10.1093/sleep/zsz133}, year = {2019}, date = {2019-06-14}, journal = {Sleep}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Chellappa, SL.; Bromundt, V; Frey, S; Steinemann, A; Schmidt, C; Schlote, T; Goldblum, D; Cajochen, C Association of Intraocular Cataract Lens Replacement With Circadian Rhythms, Cognitive Function, and Sleep in Older Adults Journal Article JAMA Ophthalmol, 2019. @article{Chellappa2019, title = {Association of Intraocular Cataract Lens Replacement With Circadian Rhythms, Cognitive Function, and Sleep in Older Adults}, author = {SL. Chellappa and V. Bromundt and S. Frey and A. Steinemann and C. Schmidt and T. Schlote and D. Goldblum and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/jamaophthalmology_chellappa_2019_oi_190029.pdf}, doi = {10.1001/jamaophthalmol.2019.1406}, year = {2019}, date = {2019-05-23}, journal = {JAMA Ophthalmol}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Zhang, Z; Cajochen, C; Khatami, R Social Jetlag and Chronotypes in the Chinese Population: Analysis of Data Recorded by Wearable Devices Journal Article J Med Internet Res, 2019. @article{Zhang2019, title = {Social Jetlag and Chronotypes in the Chinese Population: Analysis of Data Recorded by Wearable Devices}, author = {Z. Zhang and C. Cajochen and R. Khatami}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/06/fb5f17f5-08cb-47d2-885d-25b22fea372a.pdf}, doi = {10.2196/13482}, year = {2019}, date = {2019-05-11}, journal = {J Med Internet Res}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Knaier, R; Niemeyer, M; Wagner, J; Infanger, D; Hinrichs, T; Klenk, C; Frutig, S; Cajochen, C; Schmidt-Trucksäss, A Which Cutoffs for Secondary V˙O2max Criteria Are Robust to Diurnal Variations? Journal Article Med Sci Sports Exerc., 2019. @article{Knaier2019b, title = {Which Cutoffs for Secondary V˙O2max Criteria Are Robust to Diurnal Variations?}, author = {R. Knaier and M. Niemeyer and J. Wagner and D. Infanger and T. Hinrichs and C. Klenk and S. Frutig and C. Cajochen and A. Schmidt-Trucksäss}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/application-pdf.pdf}, doi = {10.1249/MSS.0000000000001869}, year = {2019}, date = {2019-05-01}, journal = {Med Sci Sports Exerc.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Brink, M; Schäffer, B; Vienneau, D; Foraster, M; Pieren, R; Eze, IC.; Cajochen, C; Probst-Hensch, N; Röösli, M; Wunderli, JM. A survey on exposure-response relationships for road, rail, and aircraft noise annoyance: Differences between continuous and intermittent noise. Journal Article Environ Int, 2019. @article{Brink2019, title = {A survey on exposure-response relationships for road, rail, and aircraft noise annoyance: Differences between continuous and intermittent noise.}, author = {M. Brink and B. Schäffer and D. Vienneau and M. Foraster and R. Pieren and IC. Eze and C. Cajochen and N. Probst-Hensch and M. Röösli and JM. Wunderli}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/1-s2.0-S016041201831897X-main.pdf}, doi = {10.1016/j.envint.2019.01.043}, year = {2019}, date = {2019-04-01}, journal = {Environ Int}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Steinemann, A; Bromundt, V; Chellappa, SL.; Frey, S; Schmidt, C; Schlote, T; Goldblum, D; Cajochen, C Klin Monbl Augenheilkd., 2019. @article{Steinemann2019, title = {Evaluation of Visual Comfort and Mental Effort Under Different Light Conditions for Ultraviolet-Absorbing and Additional Blue-Filtering Intraocular Lenses for Cataract Surgery.}, author = {A. Steinemann and V. Bromundt and SL. Chellappa and S. Frey and C. Schmidt and T. Schlote and D. Goldblum and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/a-0810-0302.pdf}, doi = {10.1055/a-0810-0302}, year = {2019}, date = {2019-04-01}, journal = {Klin Monbl Augenheilkd.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Cajochen, C; Freyburger, M; Basishvili, T; Garbazza, C; Rudzik, F; Renz, C; Kobayashi, K; Shirakawa, Y; Stefani, O; Weibel, J Effect of daylight LED on visual comfort, melatonin, mood, waking performance and sleep Journal Article 2019. @article{Cajochen2019, title = {Effect of daylight LED on visual comfort, melatonin, mood, waking performance and sleep}, author = {C. Cajochen and M. Freyburger and T. Basishvili and C. Garbazza and F. Rudzik and C. Renz and K. Kobayashi and Y. Shirakawa and O. Stefani and J. Weibel}, doi = {10.1177/1477153519828419}, year = {2019}, date = {2019-03-24}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Knaier, R; Infanger, D; Niemeyer, M; Cajochen, C; Schmidt-Trucksäss, A In Athletes, the Diurnal Variations in Maximum Oxygen Uptake Are More Than Twice as Large as the Day-to-Day Variations. Journal Article Front Physiol., 2019. @article{Knaier2019, title = {In Athletes, the Diurnal Variations in Maximum Oxygen Uptake Are More Than Twice as Large as the Day-to-Day Variations.}, author = {R. Knaier and D. Infanger and M. Niemeyer and C. Cajochen and A. Schmidt-Trucksäss}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/fphys-10-00219.pdf}, doi = {10.3389/fphys.2019.00219}, year = {2019}, date = {2019-03-18}, journal = {Front Physiol.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Vienneau, D; Héritier, H; Foraster, M; Eze, IC.; Schaffner, E; Thiesse, L; Rudzik, F; Habermacher, M; Köpfli, M; Pieren, R; Brink, M; Cajochen, C; Wunderli, JM.; Probst-Hensch, N; Röösli, M; study group, SNC Façades, floors and maps - Influence of exposure measurement error on the association between transportation noise and myocardial infarction. Journal Article Environ Int., 2019. @article{Vienneau2019, title = {Façades, floors and maps - Influence of exposure measurement error on the association between transportation noise and myocardial infarction.}, author = {D. Vienneau and H. Héritier and M. Foraster and IC. Eze and E. Schaffner and L. Thiesse and F. Rudzik and M. Habermacher and M. Köpfli and R. Pieren and M. Brink and C. Cajochen and JM. Wunderli and N. Probst-Hensch and M. Röösli and SNC study group}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/1-s2.0-S0160412018317422-main.pdf}, doi = {10.1016/j.envint.2018.12.015}, year = {2019}, date = {2019-02-01}, journal = {Environ Int.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Héritier, H; Vienneau, D; Foraster, M; Eze, IC.; Schaffner, E; de Hoogh, K; Thiesse, L; Rudzik, F; Habermacher, M; Köpfli, M; Pieren, R; Brink, M; Cajochen, C; Wunderli, JM.; Probst-Hensch, N; Röösli, M Eur Heart J., 2019. @article{Héritier2019, title = {A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland.}, author = {H. Héritier and D. Vienneau and M. Foraster and IC. Eze and E. Schaffner and K. de Hoogh and L. Thiesse and F. Rudzik and M. Habermacher and M. Köpfli and R. Pieren and M. Brink and C. Cajochen and JM. Wunderli and N. Probst-Hensch and M. Röösli}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/ehy650.pdf}, doi = {10.1093/eurheartj/ehy650}, year = {2019}, date = {2019-02-01}, journal = {Eur Heart J.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Schneeberger, AR.; Seixas, A; Schweinfurth, N; Lang, UE.; Cajochen, C; Bux, DA.; Richards, S; Jean-Louis, ; Huber, CG. Int J Environ Res Public Health, 2019. @article{Schneeberger2019, title = {Differences in Insomnia Symptoms between Immigrants and Non-Immigrants in Switzerland attributed to Emotional Distress: Analysis of the Swiss Health Survey.}, author = {AR. Schneeberger and A. Seixas and N. Schweinfurth and UE. Lang and C. Cajochen and DA. Bux and S. Richards and Jean-Louis and CG. Huber}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/ijerph-16-00289.pdf}, doi = {10.3390/ijerph16020289}, year = {2019}, date = {2019-01-21}, journal = {Int J Environ Res Public Health}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2018 |
Thiesse, L; Rudzik, F; Spiegel, K; Leproult, R; Pieren, R; Wunderli, JM.; Foraster, M; Héritier, H; Eze, IC.; Meyer, M; Vienneau, D; Brink, M; Probst-Hensch, N; Röösli, M; Cajochen, C Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: Effect of different noise scenarios. Journal Article Environ Int., 2018. @article{Thiesse2018, title = {Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: Effect of different noise scenarios.}, author = {L. Thiesse and F. Rudzik and K. Spiegel and R. Leproult and R. Pieren and JM. Wunderli and M. Foraster and H. Héritier and IC. Eze and M. Meyer and D. Vienneau and M. Brink and N. Probst-Hensch and M. Röösli and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/1-s2.0-S0160412018304252-main.pdf}, doi = {10.1016/j.envint.2018.05.036}, year = {2018}, date = {2018-12-01}, journal = {Environ Int.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Khan, S; Nobili, L; Khatami, R; Loddenkemper, T; Cajochen, C; Dijk, DJ.; Eriksson, SH. Circadian rhythm and epilepsy. Journal Article Lancet Neurol., 2018. @article{Khan2018, title = {Circadian rhythm and epilepsy.}, author = {S. Khan and L. Nobili and R. Khatami and T. Loddenkemper and C. Cajochen and DJ. Dijk and SH. Eriksson}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/1-s2.0-S1474442218303351-main.pdf}, doi = {10.1016/S1474-4422(18)30335-1}, year = {2018}, date = {2018-12-01}, journal = {Lancet Neurol.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Foraster, M; Eze, IC.; Vienneau, D; Schaffner, E; Jeong, A; Héritier, H; Rudzik, F; Thiesse, L; Pieren, R; Brink, M; Cajochen, C; Wunderli, JM.; Röösli, M; Probst-Hensch, N Long-term exposure to transportation noise and its association with adiposity markers and development of obesity. Journal Article Environ Int., 2018. @article{Foraster2018, title = {Long-term exposure to transportation noise and its association with adiposity markers and development of obesity.}, author = {M. Foraster and IC. Eze and D. Vienneau and E. Schaffner and A. Jeong and H. Héritier and F. Rudzik and L. Thiesse and R. Pieren and M. Brink and C. Cajochen and JM. Wunderli and M. Röösli and N. Probst-Hensch}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/1-s2.0-S0160412018312406-main.pdf}, doi = {10.1016/j.envint.2018.09.057}, year = {2018}, date = {2018-12-01}, journal = {Environ Int.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Eze, IC.; Foraster, M; Schaffner, E; Vienneau, D; Héritier, H; Pieren, R; Thiesse, L; Rudzik, F; Rothe, T; Pons, M; Bettschart, R; Schindler, C; Cajochen, C; Wunderli, JM.; Brink, M; Röösli, M; Probst-Hensch, N Transportation noise exposure, noise annoyance and respiratory health in adults: A repeated-measures study. Journal Article Environ Int., 2018. @article{Eze2018, title = {Transportation noise exposure, noise annoyance and respiratory health in adults: A repeated-measures study.}, author = {IC. Eze and M. Foraster and E. Schaffner and D. Vienneau and H. Héritier and R. Pieren and L. Thiesse and F. Rudzik and T. Rothe and M. Pons and R. Bettschart and C. Schindler and C. Cajochen and JM. Wunderli and M. Brink and M. Röösli and N. Probst-Hensch}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/1-s2.0-S0160412018315939-main.pdf}, doi = {10.1016/j.envint.2018.10.006}, year = {2018}, date = {2018-12-01}, journal = {Environ Int.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Lasauskaite, R; Hazelhoff, E M; Cajochen, C Four minutes might not be enough for color temperature of light to affect subjective sleepiness, mental effort, and light ratings Journal Article Lighting Research & Technology, pp. doi: 10.1177/1477153518796700, 2018. @article{, title = {Four minutes might not be enough for color temperature of light to affect subjective sleepiness, mental effort, and light ratings}, author = {R. Lasauskaite and E. M. Hazelhoff and C. Cajochen}, year = {2018}, date = {2018-08-24}, journal = {Lighting Research & Technology}, pages = {doi: 10.1177/1477153518796700}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
van der Meijden, WP.; Lindert, BHW. Te; Ramautar, JR.; Wei, Y; Coppens, JE.; Kamermans, M; Cajochen, C; Someren, Bourgin EJW. Van P Sustained effects of prior red light on pupil diameter and vigilance during subsequent darkness. Journal Article Proc Biol Sci., 2018. @article{vanderMeijden2018, title = {Sustained effects of prior red light on pupil diameter and vigilance during subsequent darkness.}, author = {WP. van der Meijden and BHW. Te Lindert and JR. Ramautar and Y. Wei and JE. Coppens and M. Kamermans and C. Cajochen and P. Bourgin EJW. Van Someren}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/05/rspb.2018.0989.pdf}, doi = {10.1098/rspb.2018.0989}, year = {2018}, date = {2018-07-18}, journal = {Proc Biol Sci.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Rudzik, F; Thiesse, L; Pieren, R; Wunderli, J M; Brink, M; Foraster, M; Héritier, H; Exe, I C; Garbazza, C; Vienneau, D; Probst-Hensch, N; Röösli, M; Cajochen, C Sleep spindle characteristics and arousability from nighttime transportation noise exposure in healthy young and older individuals. Journal Article Sleep, 41 (7), pp. doi: 10.1093/sleep/zsy077, 2018. @article{, title = {Sleep spindle characteristics and arousability from nighttime transportation noise exposure in healthy young and older individuals.}, author = {F. Rudzik and L. Thiesse and R. Pieren and J. M. Wunderli and M. Brink and M. Foraster and H. Héritier and I. C. Exe and C. Garbazza and D. Vienneau and N. Probst-Hensch and M. Röösli and C. Cajochen}, year = {2018}, date = {2018-07-01}, journal = {Sleep}, volume = {41}, number = {7}, pages = { doi: 10.1093/sleep/zsy077}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Lasauskaite, R; Cajochen, C Influence of lighting color temperature on effort-related cardiac response Journal Article Biological Psychology, 132 , pp. doi:10.1016/j.biopsycho.2017.11.005, 2018. @article{, title = {Influence of lighting color temperature on effort-related cardiac response}, author = {R. Lasauskaite and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2017/11/1-s2.0-S0301051117303186-main.pdf}, year = {2018}, date = {2018-02-01}, journal = {Biological Psychology}, volume = {132}, pages = {doi:10.1016/j.biopsycho.2017.11.005}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Maire, M; Reichert, C F; Gabel, V; Viola, A U; Phillips, C; Berthomier, C; Borgwardt, S; Cajochen, C; Schmidt, C Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement. Journal Article Scientific Reports, pp. doi: 10.1038/s41598-017-17022-9, 2018. @article{, title = {Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement.}, author = {M. Maire and C. F. Reichert and V. Gabel and A. U. Viola and C. Phillips and C. Berthomier and S. Borgwardt and C. Cajochen and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2018/09/s41598-017-17022-9.pdf}, year = {2018}, date = {2018-01-17}, journal = {Scientific Reports}, pages = {doi: 10.1038/s41598-017-17022-9}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2017 |
Gabel, V; Reichert, C F; Maire, M; Schmidt, C; Schlangen, L J M; Kolodyazhniy, V; Garbazza, C; Cajochen, C; Viola, A U Scientific Reports, 7 (7620), pp. doi:doi:10.1038/s41598-017-07060-8, 2017. @article{, title = {Differential impact in young and older individuals of blue-enriched white light on circadian physiology and alertness during sustained wakefulness}, author = {V. Gabel and C. F. Reichert and M. Maire and C. Schmidt and L. J. M. Schlangen and V. Kolodyazhniy and C. Garbazza and C. Cajochen and A. U. Viola}, url = {https://www.nature.com/articles/s41598-017-07060-8.pdf}, year = {2017}, date = {2017-08-08}, journal = {Scientific Reports}, volume = {7}, number = {7620}, pages = {doi:doi:10.1038/s41598-017-07060-8}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Reichert, C F; Maire, M; Gabel, V; Viola, A U; Götz, T; Scheffler, K; Klarhöfer, M; Berthomier, C; Strobel, W; Phillips, C; Salmon, E; Cajochen, C; Schmidt, C Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations Journal Article Scientific Reports, 7 , pp. doi:10.1038/s41598-017-05695-1, 2017. @article{644, title = {Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations}, author = {C. F. Reichert and M. Maire and V. Gabel and A. U. Viola and T. Götz and K. Scheffler and M. Klarhöfer and C. Berthomier and W. Strobel and C. Phillips and E. Salmon and C. Cajochen and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2019/03/Reichert_et_al-2017-Scientific_Reports_Cognitive-brain-responses.pdf}, year = {2017}, date = {2017-07-17}, journal = {Scientific Reports}, volume = {7}, pages = {doi:10.1038/s41598-017-05695-1}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2016 |
Baiardi, S; Cirignotta, F; Cicolin, A; Garbazza, C; D'Agostino, A; Gambini, O; Giordano, A; Canevini, M; Zambrelli, E; Marconi, A M; Mondini, S; Borgwardt, S; Cajochen, C; Rizzo, N; Manconi, M Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project Journal Article BMC Psychiatry, 16 , pp. doi:10.1186/s12888-016-1086-0, 2016. @article{, title = {Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project}, author = {S. Baiardi and F. Cirignotta and A. Cicolin and C. Garbazza and A. D'Agostino and O. Gambini and A. Giordano and M. Canevini and E. Zambrelli and A. M. Marconi and S. Mondini and S. Borgwardt and C. Cajochen and N. Rizzo and M. Manconi}, url = {http://www.chronobiology.ch/wp-content/uploads/2016/11/art3A10.11862Fs12888-016-1086-0.pdf}, year = {2016}, date = {2016-11-04}, journal = {BMC Psychiatry}, volume = {16}, pages = {doi:10.1186/s12888-016-1086-0}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Reichert, C F; Maire, M; Schmidt, C; Cajochen, C Sleep-wake regulation and its impact on working memory performance: the role of adenosine Journal Article Biology, 5 (1), pp. E11. doi:10.3390/biology5010011., 2016. @article{, title = {Sleep-wake regulation and its impact on working memory performance: the role of adenosine}, author = {C. F. Reichert and M. Maire and C. Schmidt and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2016/06/Reichert_2016.pdf}, year = {2016}, date = {2016-06-27}, journal = {Biology}, volume = {5}, number = {1}, pages = {E11. doi:10.3390/biology5010011.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Garbazza, C; Bromundt, V; Eckert, A; Brunner, D P; Meier, F; Hackethal, S; Cajochen, C Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study Journal Article Front Neurol. 2016 Feb 29;7:17 doi: 10.3389/fneur.2016.00017, 2016. @article{, title = {Non-24-Hour Sleep-Wake Disorder Revisited - A Case Study}, author = {C. Garbazza and V. Bromundt and A. Eckert and D.P. Brunner and F. Meier and S. Hackethal and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2016/06/fneur-07-00017-3.pdf}, year = {2016}, date = {2016-02-29}, journal = {Front Neurol. 2016 Feb 29;7:17 doi: 10.3389/fneur.2016.00017}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2015 |
Schmidt, C; Collette, F; Reichert, C F; Maire, M; Vandewalle, G; Peigneux, P; Cajochen, C Pushing the limits: chronotype and time of day modulate working memory-dependent cerebral activity Journal Article Frontiers in Neurology, 25 (6:199), pp. 1-9, 2015. @article{, title = {Pushing the limits: chronotype and time of day modulate working memory-dependent cerebral activity}, author = {C. Schmidt and F. Collette and C. F. Reichert and M. Maire and G. Vandewalle and P. Peigneux and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2015/10/Schmidt_etal_fneur-06-00199_15.pdf}, year = {2015}, date = {2015-10-07}, journal = {Frontiers in Neurology}, volume = {25}, number = {6:199}, pages = {1-9}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Gabel, V; Maire, M; Reichert, C F; Chellappa, S L; Schmidt, C; Hommes, V; Cajochen, C; Viola, A U Dawn simulation light impacts on different cognitive domains under sleep restriction Journal Article Behav Brain Res., doi: 10.1016/j.bbr.2014.12.043, 15 , pp. 281: 258-266, 2015. @article{, title = {Dawn simulation light impacts on different cognitive domains under sleep restriction}, author = {V. Gabel and M. Maire and C. F. Reichert and S. L. Chellappa and C. Schmidt and V. Hommes and C. Cajochen and A. U. Viola}, url = {http://www.chronobiology.ch/wp-content/uploads/2015/08/7.pdf}, year = {2015}, date = {2015-08-20}, journal = {Behav Brain Res., doi: 10.1016/j.bbr.2014.12.043}, volume = {15}, pages = {281: 258-266}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Maire, M; Reichert, C F; Gabel, V; Viola, A U; Phillips, C; Krebs, J; Scheffler, K; Klarhöfer, M; Strobel, W; Cajochen, C; Schmidt, C Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss Journal Article Ann Neurol., doi: 10.1002/ana.24434., 78(2) , pp. 235-247, 2015. @article{, title = {Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss}, author = {M. Maire and C. F. Reichert and V. Gabel and A. U. Viola and C. Phillips and J. Krebs and K. Scheffler and M. Klarhöfer and W. Strobel and C. Cajochen and C. Schmidt }, url = {http://www.chronobiology.ch/wp-content/uploads/2015/08/4.pdf}, year = {2015}, date = {2015-08-20}, journal = {Ann Neurol., doi: 10.1002/ana.24434.}, volume = {78(2)}, pages = {235-247}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
vanderLely, S; Frey, S; Garbazza, C; Wirz-Justice, A; Jenni, O G; Steiner, R; Wolf, S; Cajochen, C; Bromundt, V; Schmidt, C Blue blocker glasses as a countermeasure for alerting effects of evening light-emitting diode screen exposure in male teenagers Journal Article J Adolesc Health, doi: 10.1016/j.jadohealth.2014.08.002, 56(1) , pp. 113-119, 2015. @article{, title = {Blue blocker glasses as a countermeasure for alerting effects of evening light-emitting diode screen exposure in male teenagers}, author = {S. vanderLely and S. Frey and C. Garbazza and A. Wirz-Justice and O. G. Jenni and R. Steiner and S. Wolf and C. Cajochen and V. Bromundt and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2015/08/11.pdf}, year = {2015}, date = {2015-08-20}, journal = {J Adolesc Health, doi: 10.1016/j.jadohealth.2014.08.002}, volume = {56(1)}, pages = {113-119}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2014 |
Reichert, C F; Maire, M; Gabel, V; Hofstetter, M; Viola, A U; Kolodyazhniy, V; Strobel, W; Goetz, T; V. Bachmann, ; Landolt, H -P; Cajochen, C; Schmidt, C The Circadian Regulation of Sleep: Impact of a Functional ADA-Polymorphism and Ist Association to Working Memory Journal Article PLoS ONE, 9 (12), pp. 1-23, 2014. @article{, title = {The Circadian Regulation of Sleep: Impact of a Functional ADA-Polymorphism and Ist Association to Working Memory}, author = {C. F. Reichert and M. Maire and V. Gabel and M. Hofstetter and A.U. Viola and V. Kolodyazhniy and W. Strobel and T. Goetz and V. Bachmann and H.-P. Landolt and C. Cajochen and C. Schmidt }, url = {http://www.chronobiology.ch/wp-content/uploads/2014/12/Reichert-2014-napsleep-nback.pdf}, year = {2014}, date = {2014-12-01}, journal = {PLoS ONE}, volume = {9}, number = {12}, pages = {1-23}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Chellappa, S L; Viola, A U; Schmidt, C; Bachmann, V; Gabel, V; Maire, M; Reichert, C F; Valomon, A; Landolt, H P; Cajochen, C Light modulation of human sleep depends on a polymorphism in the clock gene Period3 Journal Article Behavioural Brain Research, 271 , pp. 23-29, 2014. @article{, title = {Light modulation of human sleep depends on a polymorphism in the clock gene Period3}, author = {S.L. Chellappa and A.U. Viola and C. Schmidt and V. Bachmann and V. Gabel and M. Maire and C. F. Reichert and A. Valomon and H.P. Landolt and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/2014/06/BBR_Chellappa_141.pdf}, year = {2014}, date = {2014-06-06}, journal = {Behavioural Brain Research}, volume = {271}, pages = {23-29}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Reichert, C F; Maire, M; Gabel, V; Viola, A U; Kolodyazhniy, V; Strobel, W; Götz, T; Bachmann, V; Landolt, H P; Cajochen, C; Schmidt, C Insights into Behavioral Vulnerability to Differential Sleep Pressure and Circadian Phase from a Functional ADA Polymorphism Journal Article Journal of Biological Rhythms, 29 (2), pp. 119-130, 2014. @article{, title = {Insights into Behavioral Vulnerability to Differential Sleep Pressure and Circadian Phase from a Functional ADA Polymorphism}, author = {C. F. Reichert and M. Maire and V. Gabel and A.U. Viola and V. Kolodyazhniy and W. Strobel and T. Götz and V. Bachmann and H.P. Landolt and C. Cajochen and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2014/04/Reichert-2014-behavioral-vulnerability1.pdf}, year = {2014}, date = {2014-04-02}, journal = {Journal of Biological Rhythms}, volume = {29}, number = {2}, pages = {119-130}, abstract = {Sleep loss affects human behavior in a nonuniform manner, depending on the cognitive domain and also the circadian phase. Besides, evidence exists about stable interindividual variations in sleep loss–related performance impairments. Despite this evidence, only a few studies have considered both circadian phase and neurobehavioral domain when investigating trait-like vulnerability to sleep manipulation. By applying a randomized, crossover design with 2 sleep pressure conditions (40 h sleep deprivation vs. 40 h multiple naps), we investigated the influence of a human adenosine deaminase (ADA) polymorphism (rs73598374) on several behavioral measures throughout nearly 2 circadian cycles. Confirming earlier studies, we observed that under sleep deprivation the previously reported vulnerable G/A-allele carriers felt overall sleepier than G/G-allele carriers. As expected, this difference was no longer present when sleep pressure was reduced by the application of multiple naps. Concomitantly, well-being was worse in the G/A genotype under sleep loss when compared to the nap protocol, and n-back working memory performance appeared to be specifically susceptible to sleep-wake manipulation in this genotype. When considering psychomotor vigilance performance, however, a higher sensitivity to sleep-wake manipulation was detected in homozygous participants, but specifically at the end of the night and only for optimal task performance. Although these data are based on a small sample size and hence require replication (12 G/A- and 12 G/G-allele carriers), they confirm the assumption that interindividual differences regarding the effect of sleep manipulation highly depend on the cognitive task and circadian phase, and thus emphasize the necessity of a multimethodological approach. Moreover, they indicate that napping might be suitable to counteract endogenously heightened sleep pressure depending on the neurobehavioral domain.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Sleep loss affects human behavior in a nonuniform manner, depending on the cognitive domain and also the circadian phase. Besides, evidence exists about stable interindividual variations in sleep loss–related performance impairments. Despite this evidence, only a few studies have considered both circadian phase and neurobehavioral domain when investigating trait-like vulnerability to sleep manipulation. By applying a randomized, crossover design with 2 sleep pressure conditions (40 h sleep deprivation vs. 40 h multiple naps), we investigated the influence of a human adenosine deaminase (ADA) polymorphism (rs73598374) on several behavioral measures throughout nearly 2 circadian cycles. Confirming earlier studies, we observed that under sleep deprivation the previously reported vulnerable G/A-allele carriers felt overall sleepier than G/G-allele carriers. As expected, this difference was no longer present when sleep pressure was reduced by the application of multiple naps. Concomitantly, well-being was worse in the G/A genotype under sleep loss when compared to the nap protocol, and n-back working memory performance appeared to be specifically susceptible to sleep-wake manipulation in this genotype. When considering psychomotor vigilance performance, however, a higher sensitivity to sleep-wake manipulation was detected in homozygous participants, but specifically at the end of the night and only for optimal task performance. Although these data are based on a small sample size and hence require replication (12 G/A- and 12 G/G-allele carriers), they confirm the assumption that interindividual differences regarding the effect of sleep manipulation highly depend on the cognitive task and circadian phase, and thus emphasize the necessity of a multimethodological approach. Moreover, they indicate that napping might be suitable to counteract endogenously heightened sleep pressure depending on the neurobehavioral domain. |
Maire, M; Reichert, C F; Gabel, V; Viola, A U; Krebs, J; Strobel, W; Landolt, H P; Bachmann, V; Cajochen, C; Schmidt, C Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation Journal Article Frontiers in Behavioral Neuroscience, 8 (59), 2014, ISSN: 1662-5153. @article{, title = {Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation}, author = {M. Maire and C. F. Reichert and V. Gabel and A.U. Viola and J. Krebs and W. Strobel and H.P. Landolt and V. Bachmann and C. Cajochen and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2014/03/Timeontask_MAIREetal2014.pdf}, issn = {1662-5153}, year = {2014}, date = {2014-03-06}, journal = {Frontiers in Behavioral Neuroscience}, volume = {8}, number = {59}, abstract = {Under sleep loss, vigilance is reduced and attentional failures emerge progressively. It becomes difficult to maintain stable performance over time, leading to growing performance variability (i.e., state instability) in an individual and among subjects. Task duration plays a major role in the maintenance of stable vigilance levels, such that the longer the task, the more likely state instability will be observed. Vulnerability to sleep-loss-dependent performance decrements is highly individual and is also modulated by a polymorphism in the human clock gene PERIOD3 (PER3). By combining two different protocols, we manipulated sleep-wake history by once extending wakefulness for 40 h (high sleep pressure condition) and once by imposing a short sleep-wake cycle by alternating 160 min of wakefulness and 80 min naps (low sleep pressure condition) in a within-subject design. We observed that homozygous carriers of the long repeat allele of PER3 (PER35/5) experienced a greater time-on-task dependent performance decrement (i.e., a steeper increase in the number of lapses) in the Psychomotor Vigilance Task compared to the carriers of the short repeat allele (PER34/4). These genotype-dependent effects disappeared under low sleep pressure conditions, and neither motivation, nor perceived effort accounted for these differences. Our data thus suggest that greater sleep-loss related attentional vulnerability based on the PER3 polymorphism is mirrored by a greater state instability under extended wakefulness in the short compared to the long allele carriers. Our results undermine the importance of time-on-task related aspects when investigating inter-individual differences in sleep loss-induced behavioral vulnerability.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Under sleep loss, vigilance is reduced and attentional failures emerge progressively. It becomes difficult to maintain stable performance over time, leading to growing performance variability (i.e., state instability) in an individual and among subjects. Task duration plays a major role in the maintenance of stable vigilance levels, such that the longer the task, the more likely state instability will be observed. Vulnerability to sleep-loss-dependent performance decrements is highly individual and is also modulated by a polymorphism in the human clock gene PERIOD3 (PER3). By combining two different protocols, we manipulated sleep-wake history by once extending wakefulness for 40 h (high sleep pressure condition) and once by imposing a short sleep-wake cycle by alternating 160 min of wakefulness and 80 min naps (low sleep pressure condition) in a within-subject design. We observed that homozygous carriers of the long repeat allele of PER3 (PER35/5) experienced a greater time-on-task dependent performance decrement (i.e., a steeper increase in the number of lapses) in the Psychomotor Vigilance Task compared to the carriers of the short repeat allele (PER34/4). These genotype-dependent effects disappeared under low sleep pressure conditions, and neither motivation, nor perceived effort accounted for these differences. Our data thus suggest that greater sleep-loss related attentional vulnerability based on the PER3 polymorphism is mirrored by a greater state instability under extended wakefulness in the short compared to the long allele carriers. Our results undermine the importance of time-on-task related aspects when investigating inter-individual differences in sleep loss-induced behavioral vulnerability. |
Maire, M; Reichert, C F; Gabel, V; Viola, A U; Strobel, W; Krebs, J; Landolt, H P; Bachmann, V; Cajochen, C; Schmidt, C Sleep ability mediates individual differences in the vulnerability to sleep loss: Evidence from a PER3 polymorphism Journal Article Cortex, http://dx.doi.org/10.1016/j.cortex.2013. , 2014. @article{, title = {Sleep ability mediates individual differences in the vulnerability to sleep loss: Evidence from a PER3 polymorphism}, author = {M. Maire and C. F. Reichert and V. Gabel and A.U. Viola and W. Strobel and J. Krebs and H.P. Landolt and V. Bachmann and C. Cajochen and C. Schmidt}, url = {http://www.chronobiology.ch/wp-content/uploads/2014/01/Maire_Cortex_2013.pdf}, year = {2014}, date = {2014-01-21}, journal = {Cortex}, volume = {http://dx.doi.org/10.1016/j.cortex.2013.}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
2013 |
Gabel, V; Maire, M; Reichert, C F; Chellappa, S L; Schmidt, C; Hommes, V; Viola, A U; Cajochen, C Effects of Artificial Dawn and Morning Blue Light on Daytime Cognitive Performance, Well-being, Cortisol and Melatonin Levels Journal Article Chronobiology International, 30 , pp. 988-97, 2013. @article{180, title = {Effects of Artificial Dawn and Morning Blue Light on Daytime Cognitive Performance, Well-being, Cortisol and Melatonin Levels}, author = {V. Gabel and M. Maire and C. F. Reichert and S.L. Chellappa and C. Schmidt and V. Hommes and A.U. Viola and C. Cajochen}, url = {http://www.chronobiology.ch/wp-content/uploads/publications/Gabel_2013.pdf}, year = {2013}, date = {2013-07-10}, journal = {Chronobiology International}, volume = {30}, pages = {988-97}, abstract = {Light exposure elicits numerous effects on human physiology and behavior, such as better cognitive performance and mood. Here we investigated the role of morning light exposure as a countermeasure for impaired cognitive performance and mood under sleep restriction (SR). Seventeen participants took part of a 48h laboratory protocol, during which three different light settings (separated by 2 wks) were administered each morning after two 6-h sleep restriction nights: a blue monochromatic LED (light-emitting diode) light condition (BL; 100 lux at 470 nm for 20 min) starting 2 h after scheduled wake-up time, a dawn-simulating light (DsL) starting 30 min before and ending 20 min after scheduled wake-up time (polychromatic light gradually increasing from 0 to 250 lux), and a dim light (DL) condition for 2 h beginning upon scheduled wake time (58 lux). Cognitive tasks were performed every 2 h during scheduled wakefulness, and questionnaires were administered hourly to assess subjective sleepiness, mood, and wellbeing. Salivary melatonin and cortisol were collected throughout scheduled wakefulness in regular intervals, and the effects on melatonin were measured after only one light pulse. Following the first SR, analysis of the time course of cognitive performance during scheduled wakefulness indicated a decrease following DL, whereas it remained stable following BL and significantly improved after DsL. Cognitive performance levels during the second day after SR were not significantly affected by the different light conditions. However, after both SR nights, mood and well-being were significantly enhanced after exposure to morning DsL compared with DL and BL. Melatonin onset occurred earlier after morning BL exposure, than after morning DsL and DL, whereas salivary cortisol levels were higher at wake-up time after DsL compared with BL and DL. Our data indicate that exposure to an artificial morning dawn simulation light improves subjective well-being, mood, and cognitive performance, as compared with DL and BL, with minimal impact on circadian phase. Thus, DsL may provide an effective strategy for enhancing cognitive performance, wellbeing, and mood under mild sleep restriction.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Light exposure elicits numerous effects on human physiology and behavior, such as better cognitive performance and mood. Here we investigated the role of morning light exposure as a countermeasure for impaired cognitive performance and mood under sleep restriction (SR). Seventeen participants took part of a 48h laboratory protocol, during which three different light settings (separated by 2 wks) were administered each morning after two 6-h sleep restriction nights: a blue monochromatic LED (light-emitting diode) light condition (BL; 100 lux at 470 nm for 20 min) starting 2 h after scheduled wake-up time, a dawn-simulating light (DsL) starting 30 min before and ending 20 min after scheduled wake-up time (polychromatic light gradually increasing from 0 to 250 lux), and a dim light (DL) condition for 2 h beginning upon scheduled wake time (58 lux). Cognitive tasks were performed every 2 h during scheduled wakefulness, and questionnaires were administered hourly to assess subjective sleepiness, mood, and wellbeing. Salivary melatonin and cortisol were collected throughout scheduled wakefulness in regular intervals, and the effects on melatonin were measured after only one light pulse. Following the first SR, analysis of the time course of cognitive performance during scheduled wakefulness indicated a decrease following DL, whereas it remained stable following BL and significantly improved after DsL. Cognitive performance levels during the second day after SR were not significantly affected by the different light conditions. However, after both SR nights, mood and well-being were significantly enhanced after exposure to morning DsL compared with DL and BL. Melatonin onset occurred earlier after morning BL exposure, than after morning DsL and DL, whereas salivary cortisol levels were higher at wake-up time after DsL compared with BL and DL. Our data indicate that exposure to an artificial morning dawn simulation light improves subjective well-being, mood, and cognitive performance, as compared with DL and BL, with minimal impact on circadian phase. Thus, DsL may provide an effective strategy for enhancing cognitive performance, wellbeing, and mood under mild sleep restriction. |